Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048948207> ?p ?o ?g. }
- W3048948207 endingPage "114196" @default.
- W3048948207 startingPage "114196" @default.
- W3048948207 abstract "When coined, the term “antisense” included oligonucleotides of any structure, with any chemical modification and designed to work through any post-RNA hybridization mechanism. However, in practice the term “antisense” has been used to describe single stranded oligonucleotides (ss ASOs) designed to hybridize to RNAs while the term “siRNA” has come to mean double stranded oligonucleotides designed to activate Ago2. However, the two approaches share many common features. The medicinal chemistry developed for ASOs greatly facilitated the development of siRNA technology and remains the chemical basis for both approaches. Many of challenges faced and solutions achieved share many common features. In fact, because ss ASOs can be designed to activate Ago2, the two approaches intersect at this remarkably important protein. There are also meaningful differences. The pharmacokinetic properties are quite different and thus potential routes of delivery differ. ASOs may be designed to use a variety of post-RNA binding mechanisms while siRNAs depend solely on the robust activity of Ago2. However, siRNAs and ASOs are both used for therapeutic purposes and both must be and can be understood in a pharmacological context. Thus, the goals of this review are to put ASOs in pharmacological context and compare their behavior as pharmacological agents to the those of siRNAs." @default.
- W3048948207 created "2020-08-18" @default.
- W3048948207 creator A5035551086 @default.
- W3048948207 creator A5039227038 @default.
- W3048948207 creator A5041988426 @default.
- W3048948207 creator A5056554811 @default.
- W3048948207 creator A5077755519 @default.
- W3048948207 date "2021-07-01" @default.
- W3048948207 modified "2023-09-26" @default.
- W3048948207 title "Antisense drug discovery and development technology considered in a pharmacological context" @default.
- W3048948207 cites W1533447420 @default.
- W3048948207 cites W1708837772 @default.
- W3048948207 cites W1889076973 @default.
- W3048948207 cites W1964227936 @default.
- W3048948207 cites W1964272339 @default.
- W3048948207 cites W1966880264 @default.
- W3048948207 cites W1968949098 @default.
- W3048948207 cites W1974509683 @default.
- W3048948207 cites W1981325894 @default.
- W3048948207 cites W1984131396 @default.
- W3048948207 cites W1990548509 @default.
- W3048948207 cites W1997689650 @default.
- W3048948207 cites W1998666145 @default.
- W3048948207 cites W2003084920 @default.
- W3048948207 cites W2011879414 @default.
- W3048948207 cites W2017443151 @default.
- W3048948207 cites W2018327969 @default.
- W3048948207 cites W2018328995 @default.
- W3048948207 cites W2020106352 @default.
- W3048948207 cites W2020469175 @default.
- W3048948207 cites W2026205222 @default.
- W3048948207 cites W2026312571 @default.
- W3048948207 cites W2027488963 @default.
- W3048948207 cites W2028833850 @default.
- W3048948207 cites W2033425827 @default.
- W3048948207 cites W2036052481 @default.
- W3048948207 cites W2037435968 @default.
- W3048948207 cites W2037695327 @default.
- W3048948207 cites W2044204671 @default.
- W3048948207 cites W2046109186 @default.
- W3048948207 cites W2050642406 @default.
- W3048948207 cites W2052322311 @default.
- W3048948207 cites W2054032118 @default.
- W3048948207 cites W2054757478 @default.
- W3048948207 cites W2055234488 @default.
- W3048948207 cites W2056750204 @default.
- W3048948207 cites W2057019601 @default.
- W3048948207 cites W2058138650 @default.
- W3048948207 cites W2059676904 @default.
- W3048948207 cites W2060734180 @default.
- W3048948207 cites W2064706592 @default.
- W3048948207 cites W2064808830 @default.
- W3048948207 cites W2067685971 @default.
- W3048948207 cites W2071746751 @default.
- W3048948207 cites W2080036080 @default.
- W3048948207 cites W2091095217 @default.
- W3048948207 cites W2093025443 @default.
- W3048948207 cites W2096917691 @default.
- W3048948207 cites W2098489216 @default.
- W3048948207 cites W2099602353 @default.
- W3048948207 cites W2102719739 @default.
- W3048948207 cites W2104954969 @default.
- W3048948207 cites W2106625506 @default.
- W3048948207 cites W2114008130 @default.
- W3048948207 cites W2127609664 @default.
- W3048948207 cites W2127848520 @default.
- W3048948207 cites W2128768698 @default.
- W3048948207 cites W2140348270 @default.
- W3048948207 cites W2141453591 @default.
- W3048948207 cites W2141695132 @default.
- W3048948207 cites W2141729181 @default.
- W3048948207 cites W2143787026 @default.
- W3048948207 cites W2156810765 @default.
- W3048948207 cites W2157085976 @default.
- W3048948207 cites W2157916750 @default.
- W3048948207 cites W2157962453 @default.
- W3048948207 cites W2160395592 @default.
- W3048948207 cites W2162215932 @default.
- W3048948207 cites W2164925969 @default.
- W3048948207 cites W2165586566 @default.
- W3048948207 cites W2166915947 @default.
- W3048948207 cites W2174791834 @default.
- W3048948207 cites W2256185547 @default.
- W3048948207 cites W2300951885 @default.
- W3048948207 cites W2314811222 @default.
- W3048948207 cites W2316492206 @default.
- W3048948207 cites W2318775098 @default.
- W3048948207 cites W2329086168 @default.
- W3048948207 cites W2334914145 @default.
- W3048948207 cites W2344362806 @default.
- W3048948207 cites W2418001336 @default.
- W3048948207 cites W2464724577 @default.
- W3048948207 cites W2473879127 @default.
- W3048948207 cites W2511893227 @default.
- W3048948207 cites W2522418769 @default.
- W3048948207 cites W2529642315 @default.
- W3048948207 cites W2542398896 @default.
- W3048948207 cites W2560182141 @default.