Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048951666> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3048951666 endingPage "412" @default.
- W3048951666 startingPage "412" @default.
- W3048951666 abstract "Background and Objectives: The opsoclonus-myoclonus syndrome (OMS) is characterised by opsoclons, myoclons and impaired balance, often concomitant with sleep disorder and behavioural difficulties. The symptoms develop as a result of autoimmune response triggered by a neuroblastic tumour (NT). OMS can also develop secondarily to a viral infection or as an immune response triggered by an unknown agent. This leads to the activation of B- and T-cells, which produce and release autoantibodies or cytokines directly within the central nervous system (CNS), thus damaging the neurons within the cerebellum and the brain stem. The available OMS treatments aim at decreasing lymphocyte, cytokine and autoantibody production or accelerating the utilisation of the latter. Another treatment option for OMS involves using cytostatic agents, which damage T- and B-cells causing their depletion and impaired function, which reduces their ability to produce antibodies and cytokines. Materials and Methods: We present a single-centre experience in treating OMS secondary to NT in 7 children. Results: The combined treatment with cyclophosphamide plus dexamethasone resulted in a complete resolution of OMS symptoms in 4 children, and a significant improvement in the 3 children. Two of them periodically present hyperactivity, and one girl requires an additional support at school due to special educational needs (SEN). Conclusions: NT resection does not resolve OMS in children with OMS secondary to NT. The combined treatment with dexamethasone plus cyclophosphamide seems to be an effective treatment of OMS." @default.
- W3048951666 created "2020-08-18" @default.
- W3048951666 creator A5012457465 @default.
- W3048951666 creator A5019262446 @default.
- W3048951666 creator A5022818791 @default.
- W3048951666 date "2020-08-14" @default.
- W3048951666 modified "2023-09-26" @default.
- W3048951666 title "The Treatment of Opsoclonus-Myoclonus Syndrome Secondary to Neuroblastic Tumours—Single-Centre Experience and Literature Review" @default.
- W3048951666 cites W1823949699 @default.
- W3048951666 cites W1977986737 @default.
- W3048951666 cites W1978162093 @default.
- W3048951666 cites W1990431746 @default.
- W3048951666 cites W2035720590 @default.
- W3048951666 cites W2047886117 @default.
- W3048951666 cites W2050746878 @default.
- W3048951666 cites W2065946731 @default.
- W3048951666 cites W2083350769 @default.
- W3048951666 cites W2108626627 @default.
- W3048951666 cites W2120200130 @default.
- W3048951666 cites W2123147772 @default.
- W3048951666 cites W2124590494 @default.
- W3048951666 cites W2132988917 @default.
- W3048951666 cites W2134921310 @default.
- W3048951666 cites W2136898065 @default.
- W3048951666 cites W2150129695 @default.
- W3048951666 cites W2151365766 @default.
- W3048951666 cites W2164174970 @default.
- W3048951666 cites W2173473353 @default.
- W3048951666 cites W2217481639 @default.
- W3048951666 cites W2256846612 @default.
- W3048951666 doi "https://doi.org/10.3390/medicina56080412" @default.
- W3048951666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7466285" @default.
- W3048951666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32823831" @default.
- W3048951666 hasPublicationYear "2020" @default.
- W3048951666 type Work @default.
- W3048951666 sameAs 3048951666 @default.
- W3048951666 citedByCount "3" @default.
- W3048951666 countsByYear W30489516662021 @default.
- W3048951666 countsByYear W30489516662022 @default.
- W3048951666 countsByYear W30489516662023 @default.
- W3048951666 crossrefType "journal-article" @default.
- W3048951666 hasAuthorship W3048951666A5012457465 @default.
- W3048951666 hasAuthorship W3048951666A5019262446 @default.
- W3048951666 hasAuthorship W3048951666A5022818791 @default.
- W3048951666 hasBestOaLocation W30489516661 @default.
- W3048951666 hasConcept C126322002 @default.
- W3048951666 hasConcept C159654299 @default.
- W3048951666 hasConcept C163764329 @default.
- W3048951666 hasConcept C203014093 @default.
- W3048951666 hasConcept C25498285 @default.
- W3048951666 hasConcept C2776538686 @default.
- W3048951666 hasConcept C2776694085 @default.
- W3048951666 hasConcept C2776755627 @default.
- W3048951666 hasConcept C2779652256 @default.
- W3048951666 hasConcept C2780401358 @default.
- W3048951666 hasConcept C42219234 @default.
- W3048951666 hasConcept C71924100 @default.
- W3048951666 hasConcept C8891405 @default.
- W3048951666 hasConceptScore W3048951666C126322002 @default.
- W3048951666 hasConceptScore W3048951666C159654299 @default.
- W3048951666 hasConceptScore W3048951666C163764329 @default.
- W3048951666 hasConceptScore W3048951666C203014093 @default.
- W3048951666 hasConceptScore W3048951666C25498285 @default.
- W3048951666 hasConceptScore W3048951666C2776538686 @default.
- W3048951666 hasConceptScore W3048951666C2776694085 @default.
- W3048951666 hasConceptScore W3048951666C2776755627 @default.
- W3048951666 hasConceptScore W3048951666C2779652256 @default.
- W3048951666 hasConceptScore W3048951666C2780401358 @default.
- W3048951666 hasConceptScore W3048951666C42219234 @default.
- W3048951666 hasConceptScore W3048951666C71924100 @default.
- W3048951666 hasConceptScore W3048951666C8891405 @default.
- W3048951666 hasIssue "8" @default.
- W3048951666 hasLocation W30489516661 @default.
- W3048951666 hasLocation W30489516662 @default.
- W3048951666 hasOpenAccess W3048951666 @default.
- W3048951666 hasPrimaryLocation W30489516661 @default.
- W3048951666 hasRelatedWork W1511775759 @default.
- W3048951666 hasRelatedWork W1983682169 @default.
- W3048951666 hasRelatedWork W1990941510 @default.
- W3048951666 hasRelatedWork W2035186592 @default.
- W3048951666 hasRelatedWork W2054557112 @default.
- W3048951666 hasRelatedWork W2092053247 @default.
- W3048951666 hasRelatedWork W2145091043 @default.
- W3048951666 hasRelatedWork W261798218 @default.
- W3048951666 hasRelatedWork W3185137146 @default.
- W3048951666 hasRelatedWork W4245460973 @default.
- W3048951666 hasVolume "56" @default.
- W3048951666 isParatext "false" @default.
- W3048951666 isRetracted "false" @default.
- W3048951666 magId "3048951666" @default.
- W3048951666 workType "article" @default.