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- W3048953509 abstract "Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt ligands (Wnts) are secreted glycoproteins and fundamentally essential for the transduction of Wnt signaling pathway. However, the 19 members of Wnts in humans imply a daunting complexity of Wnt signaling and biological effects, and our understanding of their roles in CRC tumorigenesis is still quite rudimentary. This review will give an overview of the structural characteristics and maturation process of Wnts. The expression pattern of all human Wnts in CRC tissues, including Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt9a, Wnt9b, Wnt10a, Wnt10b, Wnt11, and Wnt16, and their relationship with the tumorigenesis and the progression of CRC will be specifically summarized separately. Despite certain challenges, Wnt-based therapeutics for CRC emerge continuously and some are now in clinical trials. In conclusion, a deep understanding of Wnts is very helpful for a better management of this disease." @default.
- W3048953509 created "2020-08-18" @default.
- W3048953509 creator A5002261203 @default.
- W3048953509 creator A5020147975 @default.
- W3048953509 creator A5024584263 @default.
- W3048953509 creator A5028033336 @default.
- W3048953509 creator A5047152293 @default.
- W3048953509 date "2020-08-14" @default.
- W3048953509 modified "2023-10-12" @default.
- W3048953509 title "Emerging Roles of Wnt Ligands in Human Colorectal Cancer" @default.
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