Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048961012> ?p ?o ?g. }
- W3048961012 endingPage "9153" @default.
- W3048961012 startingPage "9136" @default.
- W3048961012 abstract "The c-myc oncogene is an important regulator for cell growth and differentiation, and its aberrant overexpression is closely related to the occurrence and development of various cancers. Thus, the suppression of c-myc transcription and expression has been investigated for cancer treatment. In this study, various new bisacridine derivatives were synthesized and evaluated for their binding with c-myc promoter G-quadruplex and i-motif. We found that a9 could bind to and stabilize both G-quadruplex and i-motif, resulting in the downregulation of c-myc gene transcription. a9 could inhibit cancer cell proliferation and induce SiHa cell apoptosis and cycle arrest. a9 exhibited tumor growth inhibition activity in a SiHa xenograft tumor model, which might be related to its binding with c-myc promoter G-quadruplex and i-motif. Our results suggested that a9 as a dual G-quadruplex/i-motif binder could be effective in both oncogene replication and transcription and become a promising lead compound for further development with improved potency and selectivity." @default.
- W3048961012 created "2020-08-18" @default.
- W3048961012 creator A5011850669 @default.
- W3048961012 creator A5013347568 @default.
- W3048961012 creator A5017464022 @default.
- W3048961012 creator A5025603106 @default.
- W3048961012 creator A5027448540 @default.
- W3048961012 creator A5045828882 @default.
- W3048961012 creator A5046448484 @default.
- W3048961012 creator A5052629732 @default.
- W3048961012 creator A5065754983 @default.
- W3048961012 creator A5082251778 @default.
- W3048961012 creator A5083861235 @default.
- W3048961012 date "2020-08-12" @default.
- W3048961012 modified "2023-10-15" @default.
- W3048961012 title "Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene <i>c-myc</i> Expression" @default.
- W3048961012 cites W1263857580 @default.
- W3048961012 cites W1966501382 @default.
- W3048961012 cites W1972485143 @default.
- W3048961012 cites W1979521450 @default.
- W3048961012 cites W1983506450 @default.
- W3048961012 cites W1988427300 @default.
- W3048961012 cites W2027047459 @default.
- W3048961012 cites W2031205304 @default.
- W3048961012 cites W2042374693 @default.
- W3048961012 cites W2062048889 @default.
- W3048961012 cites W2065665155 @default.
- W3048961012 cites W2068767022 @default.
- W3048961012 cites W2069506641 @default.
- W3048961012 cites W2075980277 @default.
- W3048961012 cites W2076746553 @default.
- W3048961012 cites W2077548707 @default.
- W3048961012 cites W2078442901 @default.
- W3048961012 cites W2088320323 @default.
- W3048961012 cites W2093321355 @default.
- W3048961012 cites W2093583881 @default.
- W3048961012 cites W2097521277 @default.
- W3048961012 cites W2102367132 @default.
- W3048961012 cites W2133009261 @default.
- W3048961012 cites W2143096086 @default.
- W3048961012 cites W2143200390 @default.
- W3048961012 cites W2149839082 @default.
- W3048961012 cites W2155773930 @default.
- W3048961012 cites W2161577298 @default.
- W3048961012 cites W2163337221 @default.
- W3048961012 cites W2322711897 @default.
- W3048961012 cites W2327094479 @default.
- W3048961012 cites W2329555214 @default.
- W3048961012 cites W2335098315 @default.
- W3048961012 cites W2483137423 @default.
- W3048961012 cites W2507972769 @default.
- W3048961012 cites W2524994322 @default.
- W3048961012 cites W2527367548 @default.
- W3048961012 cites W2553834539 @default.
- W3048961012 cites W2566222996 @default.
- W3048961012 cites W2586727998 @default.
- W3048961012 cites W2611414349 @default.
- W3048961012 cites W2612667895 @default.
- W3048961012 cites W2615814714 @default.
- W3048961012 cites W2621220151 @default.
- W3048961012 cites W2626168157 @default.
- W3048961012 cites W2724239228 @default.
- W3048961012 cites W2749895930 @default.
- W3048961012 cites W2753637112 @default.
- W3048961012 cites W2754163299 @default.
- W3048961012 cites W2756294165 @default.
- W3048961012 cites W2779006175 @default.
- W3048961012 cites W2784815753 @default.
- W3048961012 cites W2786999141 @default.
- W3048961012 cites W2800768216 @default.
- W3048961012 doi "https://doi.org/10.1021/acs.jmedchem.9b01917" @default.
- W3048961012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32787078" @default.
- W3048961012 hasPublicationYear "2020" @default.
- W3048961012 type Work @default.
- W3048961012 sameAs 3048961012 @default.
- W3048961012 citedByCount "12" @default.
- W3048961012 countsByYear W30489610122021 @default.
- W3048961012 countsByYear W30489610122022 @default.
- W3048961012 countsByYear W30489610122023 @default.
- W3048961012 crossrefType "journal-article" @default.
- W3048961012 hasAuthorship W3048961012A5011850669 @default.
- W3048961012 hasAuthorship W3048961012A5013347568 @default.
- W3048961012 hasAuthorship W3048961012A5017464022 @default.
- W3048961012 hasAuthorship W3048961012A5025603106 @default.
- W3048961012 hasAuthorship W3048961012A5027448540 @default.
- W3048961012 hasAuthorship W3048961012A5045828882 @default.
- W3048961012 hasAuthorship W3048961012A5046448484 @default.
- W3048961012 hasAuthorship W3048961012A5052629732 @default.
- W3048961012 hasAuthorship W3048961012A5065754983 @default.
- W3048961012 hasAuthorship W3048961012A5082251778 @default.
- W3048961012 hasAuthorship W3048961012A5083861235 @default.
- W3048961012 hasConcept C101762097 @default.
- W3048961012 hasConcept C104317684 @default.
- W3048961012 hasConcept C105696609 @default.
- W3048961012 hasConcept C127561419 @default.
- W3048961012 hasConcept C138885662 @default.
- W3048961012 hasConcept C150194340 @default.
- W3048961012 hasConcept C153911025 @default.