FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048970367> ?p ?o ?g. }

• W3048970367 endingPage "971" @default.
• W3048970367 startingPage "971" @default.
• W3048970367 abstract "Since its 2013 emergence in the Americas, Chikungunya virus (CHIKV) has posed a serious threat to public health. Early and accurate diagnosis of the disease, though currently lacking in clinics, is integral to enable timely care and epidemiological response. We developed a dual detection system: a CHIKV antigen E1/E2-based enzyme-linked immunosorbent assay (ELISA) and a lateral flow test using high-affinity anti-CHIKV antibodies. The ELISA was validated with 100 PCR-tested acute Chikungunya fever samples from Honduras. The assay had an overall sensitivity and specificity of 51% and 96.67%, respectively, with accuracy reaching 95.45% sensitivity and 92.03% specificity at a cycle threshold (Ct) cutoff of 22. As the Ct value decreased from 35 to 22, the ELISA sensitivity increased. We then developed and validated two lateral flow tests using independent antibody pairs. The sensitivity and specificity reached 100% for both lateral flow tests using 39 samples from Colombia and Honduras at Ct cutoffs of 20 and 27, respectively. For both lateral flow tests, sensitivity decreased as the Ct increased after 27. Because CHIKV E1/E2 are exposed in the virion surfaces in serum during the acute infection phase, these sensitive and specific assays demonstrate opportunities for early detection of this emerging human pathogen." @default.
• W3048970367 created "2020-08-18" @default.
• W3048970367 creator A5006426195 @default.
• W3048970367 creator A5008962191 @default.
• W3048970367 creator A5012246223 @default.
• W3048970367 creator A5013179785 @default.
• W3048970367 creator A5013695112 @default.
• W3048970367 creator A5016005915 @default.
• W3048970367 creator A5024951725 @default.
• W3048970367 creator A5038866221 @default.
• W3048970367 creator A5042386626 @default.
• W3048970367 creator A5052770156 @default.
• W3048970367 creator A5067369762 @default.
• W3048970367 creator A5071646394 @default.
• W3048970367 creator A5074661626 @default.
• W3048970367 creator A5083123049 @default.
• W3048970367 creator A5087932305 @default.
• W3048970367 creator A5088905471 @default.
• W3048970367 creator A5090141325 @default.
• W3048970367 creator A5090397473 @default.
• W3048970367 creator A5090471328 @default.
• W3048970367 date "2020-09-01" @default.
• W3048970367 modified "2023-10-18" @default.
• W3048970367 title "Development and Validation of a Rapid Lateral Flow E1/E2-Antigen Test and ELISA in Patients Infected with Emerging Asian Strain of Chikungunya Virus in the Americas" @default.
• W3048970367 cites W1858452149 @default.
• W3048970367 cites W1879687955 @default.
• W3048970367 cites W1964822794 @default.
• W3048970367 cites W2016636607 @default.
• W3048970367 cites W2040753525 @default.
• W3048970367 cites W2068988851 @default.
• W3048970367 cites W2078518982 @default.
• W3048970367 cites W2094084149 @default.
• W3048970367 cites W2097446992 @default.
• W3048970367 cites W2106309247 @default.
• W3048970367 cites W2113728375 @default.
• W3048970367 cites W2115306241 @default.
• W3048970367 cites W2115573034 @default.
• W3048970367 cites W2136631930 @default.
• W3048970367 cites W2141231462 @default.
• W3048970367 cites W2146545416 @default.
• W3048970367 cites W2148371183 @default.
• W3048970367 cites W2154589047 @default.
• W3048970367 cites W2156559833 @default.
• W3048970367 cites W2164231104 @default.
• W3048970367 cites W2247843536 @default.
• W3048970367 cites W2515345207 @default.
• W3048970367 cites W2624498004 @default.
• W3048970367 cites W2758691957 @default.
• W3048970367 cites W2801877261 @default.
• W3048970367 cites W2806906657 @default.
• W3048970367 cites W2904550610 @default.
• W3048970367 cites W2912035213 @default.
• W3048970367 cites W2917168681 @default.
• W3048970367 cites W2937010668 @default.
• W3048970367 cites W2946204970 @default.
• W3048970367 cites W2971742111 @default.
• W3048970367 cites W2973730802 @default.
• W3048970367 cites W2981366260 @default.
• W3048970367 cites W2981484682 @default.
• W3048970367 cites W2987151666 @default.
• W3048970367 cites W2997957069 @default.
• W3048970367 doi "https://doi.org/10.3390/v12090971" @default.
• W3048970367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7552019" @default.
• W3048970367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32882998" @default.
• W3048970367 hasPublicationYear "2020" @default.
• W3048970367 type Work @default.
• W3048970367 sameAs 3048970367 @default.
• W3048970367 citedByCount "9" @default.
• W3048970367 countsByYear W30489703672021 @default.
• W3048970367 countsByYear W30489703672022 @default.
• W3048970367 countsByYear W30489703672023 @default.
• W3048970367 crossrefType "journal-article" @default.
• W3048970367 hasAuthorship W3048970367A5006426195 @default.
• W3048970367 hasAuthorship W3048970367A5008962191 @default.
• W3048970367 hasAuthorship W3048970367A5012246223 @default.
• W3048970367 hasAuthorship W3048970367A5013179785 @default.
• W3048970367 hasAuthorship W3048970367A5013695112 @default.
• W3048970367 hasAuthorship W3048970367A5016005915 @default.
• W3048970367 hasAuthorship W3048970367A5024951725 @default.
• W3048970367 hasAuthorship W3048970367A5038866221 @default.
• W3048970367 hasAuthorship W3048970367A5042386626 @default.
• W3048970367 hasAuthorship W3048970367A5052770156 @default.
• W3048970367 hasAuthorship W3048970367A5067369762 @default.
• W3048970367 hasAuthorship W3048970367A5071646394 @default.
• W3048970367 hasAuthorship W3048970367A5074661626 @default.
• W3048970367 hasAuthorship W3048970367A5083123049 @default.
• W3048970367 hasAuthorship W3048970367A5087932305 @default.
• W3048970367 hasAuthorship W3048970367A5088905471 @default.
• W3048970367 hasAuthorship W3048970367A5090141325 @default.
• W3048970367 hasAuthorship W3048970367A5090397473 @default.
• W3048970367 hasAuthorship W3048970367A5090471328 @default.
• W3048970367 hasBestOaLocation W30489703671 @default.
• W3048970367 hasConcept C147483822 @default.
• W3048970367 hasConcept C159047783 @default.
• W3048970367 hasConcept C159654299 @default.
• W3048970367 hasConcept C203014093 @default.
• W3048970367 hasConcept C2522874641 @default.
• W3048970367 hasConcept C2781273456 @default.

• next