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- W3048972987 endingPage "504" @default.
- W3048972987 startingPage "504" @default.
- W3048972987 abstract "Pigs are highly susceptible to mycotoxins. This study investigated the effects of a postbiotic yeast cell wall-based blend (PYCW; Nicholasville, KY, USA) on growth and health of newly-weaned pigs under dietary challenge of multiple mycotoxins. Forty-eight newly-weaned pigs (21 d old) were individually allotted to four dietary treatments, based on a three phase-feeding, in a randomized complete block design (sex; initial BW) with two factors for 36 d. Two factors were dietary mycotoxins (deoxynivalenol: 2000 μg/kg supplemented in three phases; and aflatoxin: 200 μg/kg supplemented only in phase 3) and PYCW (0.2%). Growth performance (weekly), blood serum (d 34), and jejunal mucosa immune and oxidative stress markers (d 36) data were analyzed using MIXED procedure of SAS. Mycotoxins reduced (p < 0.05) average daily feed intake (ADFI) and average daily gain (ADG) during the entire period whereas PYCW did not affect growth performance. Mycotoxins reduced (p < 0.05) serum protein, albumin, creatinine, and alanine aminotransferase whereas PYCW decreased (p < 0.05) serum creatine phosphokinase. Neither mycotoxins nor PYCW affected pro-inflammatory cytokines and oxidative damage markers in the jejunal mucosa. No interaction was observed indicating that PYCW improved hepatic enzymes regardless of mycotoxin challenge. In conclusion, deoxynivalenol (2000 μg/kg, for 7 to 25 kg body weight) and aflatoxin B1 (200 μg/kg, for 16 to 25 kg body weight) impaired growth performance and nutrient digestibility of newly-weaned pigs, whereas PYCW could partially improve health of pigs regardless of mycotoxin challenge." @default.
- W3048972987 created "2020-08-18" @default.
- W3048972987 creator A5005659473 @default.
- W3048972987 creator A5082991401 @default.
- W3048972987 creator A5086732530 @default.
- W3048972987 date "2020-08-06" @default.
- W3048972987 modified "2023-10-11" @default.
- W3048972987 title "Investigation of the Efficacy of a Postbiotic Yeast Cell Wall-Based Blend on Newly-Weaned Pigs under a Dietary Challenge of Multiple Mycotoxins with Emphasis on Deoxynivalenol" @default.
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- W3048972987 doi "https://doi.org/10.3390/toxins12080504" @default.
- W3048972987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7472238" @default.
- W3048972987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32781569" @default.
- W3048972987 hasPublicationYear "2020" @default.
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