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- W3048978303 abstract "Eight new di-imines were synthesized in good yield simply by refluxing substituted benzaldehyde/pyridyl carboxaldehydes and diamine using methanol. Diamine was synthesized from acetanilide. The chemical structure of di-imines were confirmed by FT-IR, NMR, MS and elemental microanalysis. The compounds were assayed for anti-bacterial and anti-fungal activities by the disc diffusion method. Also, the in-silico ADMET study, logP prediction, biological activity score, molecular properties and Drug likeness score of these compounds were determined using Pre-ADMET, molinspiration and Molsoft online softwares respectively. ADMET study revealed that from absorption parameters human intestinal absorption value for all the synthesized di-imine was good. Similarly, the distribution property in plasma protein binding predicted that these di-imines have greater binding ability. The physical properties were determined using MolSoft. These physical properties were used to evaluate the oral bioavailability of compounds using Lipinskis rule of Five and Molecular polar surface area for drug transportation through membranes penetration." @default.
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- W3048978303 date "2020-01-01" @default.
- W3048978303 modified "2023-09-28" @default.
- W3048978303 title "Synthesis, Characterization, Antimicrobial Investigation and in-silico Screening of Di-imines Derived from 4,4′-Diaminoazobenzene" @default.
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