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- W3048980038 endingPage "13465" @default.
- W3048980038 startingPage "13444" @default.
- W3048980038 abstract "In the tumor microenvironment, unusually high concentrations of extracellular adenosine promote tumor proliferation through various immunosuppressive mechanisms. Blocking adenosine production by inhibiting nucleotide-metabolizing enzymes, such as ectonucleotidases CD73 and CD39, represents a promising therapeutic strategy that may synergize with other immuno-oncology mechanisms and chemotherapies. Emerging small-molecule ectonucleotidase inhibitors have recently entered clinical trials. This Perspective will outline challenges, strategies, and recent advancements in targeting this class with small-molecule inhibitors, including AB680, the first small-molecule CD73 inhibitor to enter clinical development. Specific case studies, including structure-based drug design and lead optimization, will be outlined. Preclinical data on these molecules and their ability to enhance antitumor immunity will be discussed." @default.
- W3048980038 created "2020-08-21" @default.
- W3048980038 creator A5071494723 @default.
- W3048980038 creator A5084561236 @default.
- W3048980038 creator A5084888956 @default.
- W3048980038 date "2020-08-13" @default.
- W3048980038 modified "2023-09-30" @default.
- W3048980038 title "Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39" @default.
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