FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048983145> ?p ?o ?g. }

• W3048983145 endingPage "1853" @default.
• W3048983145 startingPage "1840" @default.
• W3048983145 abstract "Abstract The discovery of cardiac progenitor cells (CPCs) has raised expectations for the development of cell‐based therapy of the heart. Although cell therapy is emerging as a novel treatment for heart failure, several issues still exist concerning an unambiguous definition of the phenotype of CPC types. There is a need to define and validate the methods for the generation of quality CPC populations used in cell therapy applications. Considering the critical roles of cardiac cell progenitors in cellular therapy, we speculate that long term culture might modulate the immunophenotypes of CPCs. Hence, a strategy to validate the isolation and cell culture expansion of cardiac cell populations was devised. Isolation of three subpopulations of human CPCs was done from a single tissue sample using explant, enzymatic isolation, and c‐kit + immunomagnetic sorting methods. The study assessed the effects of ex vivo expansion on proliferation, immunophenotypes, and differentiation of CPCs. Additionally, we report that an explant culture can take over 2 months to achieve similar cell yields, and cell sorting requires a much larger starting population to match this expansion time frame. In comparison, an enzymatic method is expected to yield equivalent quantities of CPCs in 2–3 weeks, notably at a significantly lower cost, which may intensify their use in therapeutic approaches. We determined that ex vivo expansion caused changes in cellular characteristics, and hence propose validated molecular signatures should be established to evaluate the impact of ex vivo expansion for a safe cell therapy product." @default.
• W3048983145 created "2020-08-21" @default.
• W3048983145 creator A5004215562 @default.
• W3048983145 creator A5076475837 @default.
• W3048983145 creator A5089200934 @default.
• W3048983145 date "2020-08-16" @default.
• W3048983145 modified "2023-10-18" @default.
• W3048983145 title "Isolation, growth kinetics, and immunophenotypic characterization of adult human cardiac progenitor cells" @default.
• W3048983145 cites W1984514695 @default.
• W3048983145 cites W1990930800 @default.
• W3048983145 cites W1997438305 @default.
• W3048983145 cites W1998668059 @default.
• W3048983145 cites W2002115156 @default.
• W3048983145 cites W2002405045 @default.
• W3048983145 cites W2010368308 @default.
• W3048983145 cites W2010417854 @default.
• W3048983145 cites W2011518964 @default.
• W3048983145 cites W2028036560 @default.
• W3048983145 cites W2031625536 @default.
• W3048983145 cites W2040708730 @default.
• W3048983145 cites W2046027917 @default.
• W3048983145 cites W2048912311 @default.
• W3048983145 cites W2055323054 @default.
• W3048983145 cites W2061532186 @default.
• W3048983145 cites W2062759770 @default.
• W3048983145 cites W2082813764 @default.
• W3048983145 cites W2084693500 @default.
• W3048983145 cites W2091099944 @default.
• W3048983145 cites W2101730981 @default.
• W3048983145 cites W2103637156 @default.
• W3048983145 cites W2105956218 @default.
• W3048983145 cites W2115862114 @default.
• W3048983145 cites W2117755053 @default.
• W3048983145 cites W2121737869 @default.
• W3048983145 cites W2122059700 @default.
• W3048983145 cites W2122414538 @default.
• W3048983145 cites W2132735690 @default.
• W3048983145 cites W2133909243 @default.
• W3048983145 cites W2137731178 @default.
• W3048983145 cites W2145331422 @default.
• W3048983145 cites W2148064846 @default.
• W3048983145 cites W2148220540 @default.
• W3048983145 cites W2151723838 @default.
• W3048983145 cites W2266910759 @default.
• W3048983145 cites W2273413272 @default.
• W3048983145 cites W2535147344 @default.
• W3048983145 cites W2557992698 @default.
• W3048983145 cites W2602216509 @default.
• W3048983145 cites W2604800845 @default.
• W3048983145 cites W2608308545 @default.
• W3048983145 cites W2625029054 @default.
• W3048983145 cites W2736842962 @default.
• W3048983145 cites W2744042034 @default.
• W3048983145 cites W2765576802 @default.
• W3048983145 cites W2808941682 @default.
• W3048983145 cites W4289253660 @default.
• W3048983145 doi "https://doi.org/10.1002/jcp.29965" @default.
• W3048983145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33242343" @default.
• W3048983145 hasPublicationYear "2020" @default.
• W3048983145 type Work @default.
• W3048983145 sameAs 3048983145 @default.
• W3048983145 citedByCount "0" @default.
• W3048983145 crossrefType "journal-article" @default.
• W3048983145 hasAuthorship W3048983145A5004215562 @default.
• W3048983145 hasAuthorship W3048983145A5076475837 @default.
• W3048983145 hasAuthorship W3048983145A5089200934 @default.
• W3048983145 hasConcept C10882517 @default.
• W3048983145 hasConcept C1491633281 @default.
• W3048983145 hasConcept C201750760 @default.
• W3048983145 hasConcept C203014093 @default.
• W3048983145 hasConcept C207001950 @default.
• W3048983145 hasConcept C26291073 @default.
• W3048983145 hasConcept C2778630268 @default.
• W3048983145 hasConcept C28328180 @default.
• W3048983145 hasConcept C2908647359 @default.
• W3048983145 hasConcept C54355233 @default.
• W3048983145 hasConcept C62112901 @default.
• W3048983145 hasConcept C70721500 @default.
• W3048983145 hasConcept C71924100 @default.
• W3048983145 hasConcept C86803240 @default.
• W3048983145 hasConcept C95444343 @default.
• W3048983145 hasConcept C99454951 @default.
• W3048983145 hasConceptScore W3048983145C10882517 @default.
• W3048983145 hasConceptScore W3048983145C1491633281 @default.
• W3048983145 hasConceptScore W3048983145C201750760 @default.
• W3048983145 hasConceptScore W3048983145C203014093 @default.
• W3048983145 hasConceptScore W3048983145C207001950 @default.
• W3048983145 hasConceptScore W3048983145C26291073 @default.
• W3048983145 hasConceptScore W3048983145C2778630268 @default.
• W3048983145 hasConceptScore W3048983145C28328180 @default.
• W3048983145 hasConceptScore W3048983145C2908647359 @default.
• W3048983145 hasConceptScore W3048983145C54355233 @default.
• W3048983145 hasConceptScore W3048983145C62112901 @default.
• W3048983145 hasConceptScore W3048983145C70721500 @default.
• W3048983145 hasConceptScore W3048983145C71924100 @default.
• W3048983145 hasConceptScore W3048983145C86803240 @default.
• W3048983145 hasConceptScore W3048983145C95444343 @default.
• W3048983145 hasConceptScore W3048983145C99454951 @default.

• next