Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048984944> ?p ?o ?g. }
- W3048984944 abstract "Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-related neurological dysfunction. A lack of biomarkers of TBI has impeded medication development. To identify new potential biomarkers, we time-dependently evaluated mouse brain tissue and neuronally derived plasma extracellular vesicle proteins in a mild model of TBI with parallels to concussive head injury. Mice (CD-1, 30–40 g) received a sham procedure or 30 g weight-drop and were euthanized 8, 24, 48, 72, 96 hr, 7, 14 and 30 days later. We quantified ipsilateral cortical proteins, many of which differed from sham by 8 hours post-mTBI, particularly GAS-1 and VEGF-B were increased while CXCL16 reduced, 23 proteins changed in 4 or more of the time points. Gene ontology pathways mapped from altered proteins over time related to pathological and physiological processes. Validation of proteins identified in this study may provide utility as treatment response biomarkers." @default.
- W3048984944 created "2020-08-21" @default.
- W3048984944 creator A5013311937 @default.
- W3048984944 creator A5019721067 @default.
- W3048984944 creator A5028464969 @default.
- W3048984944 creator A5031854067 @default.
- W3048984944 creator A5056649584 @default.
- W3048984944 creator A5063213339 @default.
- W3048984944 creator A5077439065 @default.
- W3048984944 creator A5086984046 @default.
- W3048984944 date "2020-08-17" @default.
- W3048984944 modified "2023-09-25" @default.
- W3048984944 title "Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury" @default.
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