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- W3048993321 abstract "Abstract During recent decades, neurodegenerative disorders have become a critical issue in public health. Among these disorders, Alzheimer disease (AD) constitutes the primary cause of dementia in the elderly population. AD is clinically characterized by the following histopathological hallmarks: progressive memory impairment, senile plaque deposition, and neurofibrillary tangle inclusions. Although several hypotheses have been proposed to explain AD pathophysiology, the triggering factor of the primary molecular event in the pathophysiological chain remains undetermined. In this regard, neuroinflammation has emerged as critical for the establishment and progression of AD. Age-related proinflammatory status and a severe neuroinflammatory response are part of the pathological scenario. In addition to the glial reactivity, the cross talk between inflammatory mediators and several signaling pathways depicts an intricate molecular network that can determine neuronal fate. Thus, in this chapter, we address the complexity of the inflammatory milieu and its contribution to the establishment and progression of AD." @default.
- W3048993321 created "2020-08-21" @default.
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- W3048993321 date "2020-01-01" @default.
- W3048993321 modified "2023-10-18" @default.
- W3048993321 title "Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegeneration" @default.
- W3048993321 doi "https://doi.org/10.1016/b978-0-12-815868-5.00011-6" @default.
- W3048993321 hasPublicationYear "2020" @default.
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