Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049012005> ?p ?o ?g. }
- W3049012005 endingPage "29" @default.
- W3049012005 startingPage "14" @default.
- W3049012005 abstract "Abstract Despite the existing arsenal of anti‐cancer drugs, 10 million people die each year worldwide due to cancers; this highlights the need to discover new therapies based on innovative modes of action against these pathologies. Current chemotherapies are based on the use of cytotoxic agents, targeted drugs, monoclonal antibodies or immunotherapies that are able to reduce or stop the proliferation of cancer cells. However, tumor eradication is often hampered by the presence of resistant cells called cancer stem‐like cells or cancer stem cells (CSCs). Several strategies have been proposed to specifically target CSCs such as the use of CSC‐specific antibodies, small molecules able to target CSC signaling pathways or drugs able to induce CSC differentiation rendering them sensitive to classical chemotherapy. These latter compounds are the focus of the present review, which aims to report recent advances in anticancer‐differentiation strategies. This therapeutic approach was shown to be particularly promising for eradicating tumors in which CSCs are the main reason for therapeutic failure. This general view of the chemistry and mechanism of action of compounds inducing the differentiation of CSCs could be particularly useful for a broad range of researchers working in the field of anticancer therapies as the combination of compounds that induce differentiation with classical chemotherapy could represent a successful approach for future therapeutic applications." @default.
- W3049012005 created "2020-08-21" @default.
- W3049012005 creator A5047878863 @default.
- W3049012005 creator A5061827434 @default.
- W3049012005 creator A5076235408 @default.
- W3049012005 creator A5090269367 @default.
- W3049012005 date "2020-09-16" @default.
- W3049012005 modified "2023-09-25" @default.
- W3049012005 title "Differentiation of Cancer Stem Cells by Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance" @default.
- W3049012005 cites W1500827124 @default.
- W3049012005 cites W1781170077 @default.
- W3049012005 cites W1891848729 @default.
- W3049012005 cites W1964427001 @default.
- W3049012005 cites W1966461436 @default.
- W3049012005 cites W1968177744 @default.
- W3049012005 cites W1970010835 @default.
- W3049012005 cites W1977962361 @default.
- W3049012005 cites W1979421565 @default.
- W3049012005 cites W1981910809 @default.
- W3049012005 cites W1984413324 @default.
- W3049012005 cites W1992187858 @default.
- W3049012005 cites W1995724436 @default.
- W3049012005 cites W1998728654 @default.
- W3049012005 cites W2001723288 @default.
- W3049012005 cites W2005144663 @default.
- W3049012005 cites W2006307101 @default.
- W3049012005 cites W2007255793 @default.
- W3049012005 cites W2008720321 @default.
- W3049012005 cites W2009443452 @default.
- W3049012005 cites W2009886857 @default.
- W3049012005 cites W2015755329 @default.
- W3049012005 cites W2020913470 @default.
- W3049012005 cites W2024294363 @default.
- W3049012005 cites W2024430424 @default.
- W3049012005 cites W2025299523 @default.
- W3049012005 cites W2026967508 @default.
- W3049012005 cites W2028243804 @default.
- W3049012005 cites W2033314544 @default.
- W3049012005 cites W2036088433 @default.
- W3049012005 cites W2037082754 @default.
- W3049012005 cites W2037691690 @default.
- W3049012005 cites W2039109621 @default.
- W3049012005 cites W2043046186 @default.
- W3049012005 cites W2043422478 @default.
- W3049012005 cites W2043954875 @default.
- W3049012005 cites W2044413378 @default.
- W3049012005 cites W2048639599 @default.
- W3049012005 cites W2049820663 @default.
- W3049012005 cites W2051071528 @default.
- W3049012005 cites W2052647271 @default.
- W3049012005 cites W2064044156 @default.
- W3049012005 cites W2064212361 @default.
- W3049012005 cites W2068850165 @default.
- W3049012005 cites W2070616554 @default.
- W3049012005 cites W2074944221 @default.
- W3049012005 cites W2075873658 @default.
- W3049012005 cites W2077575239 @default.
- W3049012005 cites W2085570457 @default.
- W3049012005 cites W2087128761 @default.
- W3049012005 cites W2089593640 @default.
- W3049012005 cites W2090982381 @default.
- W3049012005 cites W2091269867 @default.
- W3049012005 cites W2102085111 @default.
- W3049012005 cites W2102376919 @default.
- W3049012005 cites W2102650381 @default.
- W3049012005 cites W2104600818 @default.
- W3049012005 cites W2105549148 @default.
- W3049012005 cites W2106873042 @default.
- W3049012005 cites W2108177844 @default.
- W3049012005 cites W2109805795 @default.
- W3049012005 cites W2115001053 @default.
- W3049012005 cites W2115279327 @default.
- W3049012005 cites W2116986041 @default.
- W3049012005 cites W2117692326 @default.
- W3049012005 cites W2120656656 @default.
- W3049012005 cites W2129338773 @default.
- W3049012005 cites W2129737089 @default.
- W3049012005 cites W2131809108 @default.
- W3049012005 cites W2137631271 @default.
- W3049012005 cites W2138226825 @default.
- W3049012005 cites W2141083396 @default.
- W3049012005 cites W2141916150 @default.
- W3049012005 cites W2143570904 @default.
- W3049012005 cites W2147745959 @default.
- W3049012005 cites W2151300092 @default.
- W3049012005 cites W2155101269 @default.
- W3049012005 cites W2155507705 @default.
- W3049012005 cites W2155959079 @default.
- W3049012005 cites W2163036693 @default.
- W3049012005 cites W2163169932 @default.
- W3049012005 cites W2163976460 @default.
- W3049012005 cites W2168526678 @default.
- W3049012005 cites W2171998898 @default.
- W3049012005 cites W2181260619 @default.
- W3049012005 cites W2231088500 @default.
- W3049012005 cites W2237670980 @default.
- W3049012005 cites W2261100060 @default.
- W3049012005 cites W2290224694 @default.