Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049014778> ?p ?o ?g. }
- W3049014778 endingPage "5901" @default.
- W3049014778 startingPage "5901" @default.
- W3049014778 abstract "Gastric cancer (GC) is among the most treatment-refractory epithelial malignancies. Aberrant activation of Wnt/β-catenin-signaling has been implicated in a variety of human cancers, including gastric cancer. Here we report that the elevated expression of lymphoid enhancer binding factor 1 (Lef1) is associated with the TNM (tumor– node–metastasis) stage of gastric cancer. Subsequently, 2,4-diamino-quinazoline (2,4-DAQ), a selective inhibitor of Lef1, was identified to suppress the expression of Wnt/β-catenin target genes such as AXIN2, MYC and LGR5 and result in the suppression of gastric cancer cell growth through the apoptotic pathway. The 2,4-DAQ also exhibited an inhibitory effect on the migration/invasion of gastric cancer cells. Importantly, the treatment of human gastric tumor xenograft with 2,4-DAQ suppressed tumor growth in a nude mouse model. Furthermore, 2,4-DAQ appears effective on patient-derived organoids (PDOs). Transcriptome sequencing analysis also revealed that 2,4-DAQ are more effective on the gastric cancers that exhibit higher expression levels of Wnt-signaling pathway-related genes than their adjacent normal gastric tissues." @default.
- W3049014778 created "2020-08-21" @default.
- W3049014778 creator A5012428737 @default.
- W3049014778 creator A5013517994 @default.
- W3049014778 creator A5021453806 @default.
- W3049014778 creator A5027629838 @default.
- W3049014778 creator A5038905352 @default.
- W3049014778 creator A5041975586 @default.
- W3049014778 creator A5057295649 @default.
- W3049014778 creator A5073313935 @default.
- W3049014778 creator A5086810877 @default.
- W3049014778 date "2020-08-17" @default.
- W3049014778 modified "2023-09-29" @default.
- W3049014778 title "2,4-Diamino-Quinazoline, a Wnt Signaling Inhibitor, Suppresses Gastric Cancer Progression and Metastasis" @default.
- W3049014778 cites W1741548448 @default.
- W3049014778 cites W1875373156 @default.
- W3049014778 cites W1963501822 @default.
- W3049014778 cites W1969080191 @default.
- W3049014778 cites W1975481178 @default.
- W3049014778 cites W1985350996 @default.
- W3049014778 cites W1988845690 @default.
- W3049014778 cites W2044862506 @default.
- W3049014778 cites W2048672944 @default.
- W3049014778 cites W2052891178 @default.
- W3049014778 cites W2069505779 @default.
- W3049014778 cites W2071123870 @default.
- W3049014778 cites W2076777729 @default.
- W3049014778 cites W2087500600 @default.
- W3049014778 cites W2091874844 @default.
- W3049014778 cites W2100439220 @default.
- W3049014778 cites W2108947370 @default.
- W3049014778 cites W2110444464 @default.
- W3049014778 cites W2118636857 @default.
- W3049014778 cites W2122724788 @default.
- W3049014778 cites W2126547130 @default.
- W3049014778 cites W2147864074 @default.
- W3049014778 cites W2148287035 @default.
- W3049014778 cites W2157364449 @default.
- W3049014778 cites W2161080156 @default.
- W3049014778 cites W2338576041 @default.
- W3049014778 cites W2522383043 @default.
- W3049014778 cites W2565163655 @default.
- W3049014778 cites W2589317690 @default.
- W3049014778 cites W2604415318 @default.
- W3049014778 cites W2725634124 @default.
- W3049014778 cites W2788735115 @default.
- W3049014778 cites W2792603544 @default.
- W3049014778 cites W2799335786 @default.
- W3049014778 cites W2806934642 @default.
- W3049014778 cites W2885126750 @default.
- W3049014778 cites W2889646458 @default.
- W3049014778 cites W2890912772 @default.
- W3049014778 cites W2902731954 @default.
- W3049014778 cites W2913284684 @default.
- W3049014778 cites W2914135414 @default.
- W3049014778 cites W2948402706 @default.
- W3049014778 cites W2953247674 @default.
- W3049014778 cites W4211130279 @default.
- W3049014778 cites W4253225734 @default.
- W3049014778 doi "https://doi.org/10.3390/ijms21165901" @default.
- W3049014778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7460562" @default.
- W3049014778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32824603" @default.
- W3049014778 hasPublicationYear "2020" @default.
- W3049014778 type Work @default.
- W3049014778 sameAs 3049014778 @default.
- W3049014778 citedByCount "8" @default.
- W3049014778 countsByYear W30490147782021 @default.
- W3049014778 countsByYear W30490147782022 @default.
- W3049014778 countsByYear W30490147782023 @default.
- W3049014778 crossrefType "journal-article" @default.
- W3049014778 hasAuthorship W3049014778A5012428737 @default.
- W3049014778 hasAuthorship W3049014778A5013517994 @default.
- W3049014778 hasAuthorship W3049014778A5021453806 @default.
- W3049014778 hasAuthorship W3049014778A5027629838 @default.
- W3049014778 hasAuthorship W3049014778A5038905352 @default.
- W3049014778 hasAuthorship W3049014778A5041975586 @default.
- W3049014778 hasAuthorship W3049014778A5057295649 @default.
- W3049014778 hasAuthorship W3049014778A5073313935 @default.
- W3049014778 hasAuthorship W3049014778A5086810877 @default.
- W3049014778 hasBestOaLocation W30490147781 @default.
- W3049014778 hasConcept C121608353 @default.
- W3049014778 hasConcept C137620995 @default.
- W3049014778 hasConcept C2779013556 @default.
- W3049014778 hasConcept C502942594 @default.
- W3049014778 hasConcept C54355233 @default.
- W3049014778 hasConcept C62478195 @default.
- W3049014778 hasConcept C86803240 @default.
- W3049014778 hasConcept C95444343 @default.
- W3049014778 hasConcept C96232424 @default.
- W3049014778 hasConcept C99732316 @default.
- W3049014778 hasConceptScore W3049014778C121608353 @default.
- W3049014778 hasConceptScore W3049014778C137620995 @default.
- W3049014778 hasConceptScore W3049014778C2779013556 @default.
- W3049014778 hasConceptScore W3049014778C502942594 @default.
- W3049014778 hasConceptScore W3049014778C54355233 @default.
- W3049014778 hasConceptScore W3049014778C62478195 @default.
- W3049014778 hasConceptScore W3049014778C86803240 @default.
- W3049014778 hasConceptScore W3049014778C95444343 @default.