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- W3049021736 abstract "Genome-wide association studies have found an association between the PICALM genotype and Alzheimer disease. PICALM is involved in clathrin-mediated endocytosis and may contribute to the pathogenesis of Alzheimer disease through several pathways, including beta-amyloid production, impaired clearance of brain beta-amyloid and tau proteins, and synaptic dysfunction. The neurophysiological alterations in nondemented carriers of the PICALM GG rs3851179 risk variant for Alzheimer disease manifest in beta power elevation in resting electroencephalography during ageing, suggesting cortical disinhibition and hyperexcitability. PICALM GG carriers also exhibit delayed event-related potential P300 latency in ageing compared to PICALM GG noncarriers, indicating a decline in cognitive processing speed. The neurophysiological alterations may account for age-related cognitive deficits in PICALM GG carriers. We review current knowledge about the metabolic pathways of PICALM, the association of PICALM genotype with neurophysiological alterations during ageing, and we discuss the mechanisms underlying these alterations and their role in the pathogenesis of Alzheimer disease." @default.
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- W3049021736 date "2020-01-01" @default.
- W3049021736 modified "2023-10-12" @default.
- W3049021736 title "Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) gene" @default.
- W3049021736 doi "https://doi.org/10.1016/b978-0-12-815868-5.00003-7" @default.
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