FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049028489> ?p ?o ?g. }

• W3049028489 abstract "Background: Levosimendan, a calcium sensitizer, enhances the myocardial function by generating more energy-efficient myocardial contractility than that achieved through adrenergic stimulation with catecholamines. We conducted this meta-analysis to primarily investigate the effects of levosimendan on all-cause mortality in pediatric patients undergoing cardiac surgery under cardiopulmonary bypass. Methods: The databases of Pubmed, Embase, and Cochrane Library were searched till 21st March 2020. The eligible criteria were participants with age<18 year and undergoing cardiac surgery for congenital heart disease (CHD), and studies of comparison between levosimendan and placebo or other inotropes. Stata version 12.0 was used to perform statistical analyses. Results: Six randomized controlled trials (RCTs) and 1 case-control trial (CCT) including 436 patients were included. The results showed that levosimendan did not significantly decrease all-cause mortality compared with control drugs (and placebo) in children undergoing cardiac surgery (P = 0.403). Perioperative prophylactic levosimendan administration strikingly decreased the low cardiac output syndrome (LCOS) incidence (P = 0.016) but did not significantly reduce acute kidney injury (AKI) incidence (P = 0.251) and shorten mechanical ventilation and ICU stay time compared with other inotropes and placebo by analyzing the included literatures [mechanical ventilation (or intubation) time: P = 0.188; ICU stay time: P = 0.620]. Conclusions: Compared with other inotropes and placebo, perioperative prophylactic administration of levosimendan did not decrease the rates of mortality and AKI and shorten the time of mechanical ventilation (or intubation) and ICU stay but demonstrated a significant reduction in LCOS incidence after corrective surgery in pediatric patients for CHD. Due to limited number of included studies, the current data were insufficient to make the conclusions." @default.
• W3049028489 created "2020-08-21" @default.
• W3049028489 creator A5000093771 @default.
• W3049028489 creator A5034745076 @default.
• W3049028489 creator A5036869641 @default.
• W3049028489 creator A5064137416 @default.
• W3049028489 creator A5070842420 @default.
• W3049028489 creator A5081560512 @default.
• W3049028489 date "2020-08-14" @default.
• W3049028489 modified "2023-09-25" @default.
• W3049028489 title "Effect of Prophylactic Levosimendan on All-Cause Mortality in Pediatric Patients Undergoing Cardiac Surgery—An Updated Systematic Review and Meta-Analysis" @default.
• W3049028489 cites W1963546783 @default.
• W3049028489 cites W1971861988 @default.
• W3049028489 cites W1979701485 @default.
• W3049028489 cites W2022600403 @default.
• W3049028489 cites W2024113368 @default.
• W3049028489 cites W2029532220 @default.
• W3049028489 cites W2029794453 @default.
• W3049028489 cites W2030701908 @default.
• W3049028489 cites W2046724909 @default.
• W3049028489 cites W2053971257 @default.
• W3049028489 cites W2061463574 @default.
• W3049028489 cites W2067839119 @default.
• W3049028489 cites W2080956449 @default.
• W3049028489 cites W2085028768 @default.
• W3049028489 cites W2085868271 @default.
• W3049028489 cites W2103786102 @default.
• W3049028489 cites W2127651839 @default.
• W3049028489 cites W2135242378 @default.
• W3049028489 cites W2138373808 @default.
• W3049028489 cites W2149818341 @default.
• W3049028489 cites W2155827592 @default.
• W3049028489 cites W2156098321 @default.
• W3049028489 cites W2172894563 @default.
• W3049028489 cites W2325219355 @default.
• W3049028489 cites W2334558964 @default.
• W3049028489 cites W2340556948 @default.
• W3049028489 cites W2468996569 @default.
• W3049028489 cites W2594672943 @default.
• W3049028489 cites W2615851405 @default.
• W3049028489 cites W2752399807 @default.
• W3049028489 cites W2753426284 @default.
• W3049028489 cites W2759589333 @default.
• W3049028489 cites W2795052073 @default.
• W3049028489 cites W2802336147 @default.
• W3049028489 cites W2804236385 @default.
• W3049028489 cites W2885502375 @default.
• W3049028489 cites W2887751713 @default.
• W3049028489 cites W2889071925 @default.
• W3049028489 cites W2894118276 @default.
• W3049028489 cites W2895505937 @default.
• W3049028489 cites W2896074137 @default.
• W3049028489 cites W2911110553 @default.
• W3049028489 cites W2941436553 @default.
• W3049028489 cites W2942728546 @default.
• W3049028489 cites W2972798301 @default.
• W3049028489 cites W2997499291 @default.
• W3049028489 cites W3012207199 @default.
• W3049028489 doi "https://doi.org/10.3389/fped.2020.00456" @default.
• W3049028489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7456871" @default.
• W3049028489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32923414" @default.
• W3049028489 hasPublicationYear "2020" @default.
• W3049028489 type Work @default.
• W3049028489 sameAs 3049028489 @default.
• W3049028489 citedByCount "12" @default.
• W3049028489 countsByYear W30490284892021 @default.
• W3049028489 countsByYear W30490284892022 @default.
• W3049028489 countsByYear W30490284892023 @default.
• W3049028489 crossrefType "journal-article" @default.
• W3049028489 hasAuthorship W3049028489A5000093771 @default.
• W3049028489 hasAuthorship W3049028489A5034745076 @default.
• W3049028489 hasAuthorship W3049028489A5036869641 @default.
• W3049028489 hasAuthorship W3049028489A5064137416 @default.
• W3049028489 hasAuthorship W3049028489A5070842420 @default.
• W3049028489 hasAuthorship W3049028489A5081560512 @default.
• W3049028489 hasBestOaLocation W30490284891 @default.
• W3049028489 hasConcept C126322002 @default.
• W3049028489 hasConcept C142724271 @default.
• W3049028489 hasConcept C155710745 @default.
• W3049028489 hasConcept C164705383 @default.
• W3049028489 hasConcept C168563851 @default.
• W3049028489 hasConcept C204787440 @default.
• W3049028489 hasConcept C27081682 @default.
• W3049028489 hasConcept C2776478404 @default.
• W3049028489 hasConcept C2777080012 @default.
• W3049028489 hasConcept C2777335384 @default.
• W3049028489 hasConcept C2778716859 @default.
• W3049028489 hasConcept C2778789114 @default.
• W3049028489 hasConcept C2778881276 @default.
• W3049028489 hasConcept C2780472472 @default.
• W3049028489 hasConcept C31174226 @default.
• W3049028489 hasConcept C42219234 @default.
• W3049028489 hasConcept C71924100 @default.
• W3049028489 hasConceptScore W3049028489C126322002 @default.
• W3049028489 hasConceptScore W3049028489C142724271 @default.
• W3049028489 hasConceptScore W3049028489C155710745 @default.
• W3049028489 hasConceptScore W3049028489C164705383 @default.
• W3049028489 hasConceptScore W3049028489C168563851 @default.
• W3049028489 hasConceptScore W3049028489C204787440 @default.
• W3049028489 hasConceptScore W3049028489C27081682 @default.

• next