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- W3049029236 abstract "Astrocytes in primary culture express receptors for monoamine and peptide neurotransmitters. The cells also exhibit uptake sites for amino acid neurotransmitters. New data is presented, demonstrating interactions between the second messenger systems for vasoactive intestinal peptide (VIP) and α- and β-adrenoceptors. Stimulation of these monoamine receptors modulates GABA and glutamate uptake into the cells, which indicates that astrocytes have the capacity to supervise and regulate synaptic transmission. Morphine affects astrocytes directly, probably by interaction with α 2 receptors, and indirectly by drug-induced ionic changes in the synaptic region, followed by changes in neurotransmission and protein synthesis. Modulation of astroglial specific functions or metabolism might be one way to affect functional neuronal disturbances, including an approach toward understanding the underlying cellular mechanisms, e.g. tolerance." @default.
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- W3049029236 date "1988-03-01" @default.
- W3049029236 modified "2023-10-13" @default.
- W3049029236 title "Does Morphine Affect Astrocytes?" @default.
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- W3049029236 doi "https://doi.org/10.1177/026119298801500312" @default.
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