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- W3049029268 abstract "To study short and long-term effects of acute ocular hypertension (AOHT) on inner and outer retinal layers, in adult Sprague-Dawley rats AOHT (87 mmHg) was induced for 90 min and the retinas were examined longitudinally in vivo with electroretinogram (ERG) recordings and optical coherent tomography (OCT) from 1 to 90 days (d). Ex vivo, the retinas were analyzed for rod (RBC) and cone (CBC) bipolar cells, with antibodies against protein kinase Cα and recoverin, respectively in cross sections, and for cones, horizontal (HZ) and ganglion (RGC) cells with antibodies against arrestin, calbindin and Brn3a, respectively in wholemounts. The inner retina thinned progressively up to 7 d with no further changes, while the external retina had a normal thickness until 30 d, with a 20% thinning between 30 and 90 d. Functionally, the a-wave showed an initial reduction by 24 h and a further reduction from 30 to 90 d. All other main ERG waves were significantly reduced by 1 d without significant recovery by 90 d. Radial sections showed a normal population of RBCs but their terminals were reduced. The CBCs showed a progressive decrease with a loss of 56% by 30 d. In wholemount retinas, RGCs diminished to 40% by 3 d and to 16% by 30 d without further loss. Cones diminished to 58% and 35% by 3 and 7 d, respectively and further decreased between 30 and 90 d. HZs showed normal values throughout the study. In conclusion, AOHT affects both the inner and outer retina, with a more pronounced degeneration of the cone than the rod pathway." @default.
- W3049029268 created "2020-08-21" @default.
- W3049029268 creator A5000484003 @default.
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- W3049029268 date "2020-01-01" @default.
- W3049029268 modified "2023-10-18" @default.
- W3049029268 title "Functional and morphological alterations in a glaucoma model of acute ocular hypertension" @default.
- W3049029268 cites W1480633375 @default.
- W3049029268 cites W1570680339 @default.
- W3049029268 cites W1598553549 @default.
- W3049029268 cites W1817134384 @default.
- W3049029268 cites W1964003114 @default.
- W3049029268 cites W1964207930 @default.
- W3049029268 cites W1968132598 @default.
- W3049029268 cites W1971064773 @default.
- W3049029268 cites W1972747837 @default.
- W3049029268 cites W1977423618 @default.
- W3049029268 cites W1981121080 @default.
- W3049029268 cites W1983150598 @default.
- W3049029268 cites W1984131146 @default.
- W3049029268 cites W1985794479 @default.
- W3049029268 cites W1991496715 @default.
- W3049029268 cites W1992918086 @default.
- W3049029268 cites W1996902595 @default.
- W3049029268 cites W1997810133 @default.
- W3049029268 cites W2007717174 @default.
- W3049029268 cites W2009133239 @default.
- W3049029268 cites W2009477155 @default.
- W3049029268 cites W2010247968 @default.
- W3049029268 cites W2012852176 @default.
- W3049029268 cites W2015021962 @default.
- W3049029268 cites W2015951890 @default.
- W3049029268 cites W2016444344 @default.
- W3049029268 cites W2018767813 @default.
- W3049029268 cites W2019116868 @default.
- W3049029268 cites W2019210417 @default.
- W3049029268 cites W2020567717 @default.
- W3049029268 cites W2021499247 @default.
- W3049029268 cites W2025800996 @default.
- W3049029268 cites W2029390749 @default.
- W3049029268 cites W2033445946 @default.
- W3049029268 cites W2034262791 @default.
- W3049029268 cites W2034742711 @default.
- W3049029268 cites W2035029504 @default.
- W3049029268 cites W2045620761 @default.
- W3049029268 cites W2046148238 @default.
- W3049029268 cites W2049918942 @default.
- W3049029268 cites W2057266151 @default.
- W3049029268 cites W2059932450 @default.
- W3049029268 cites W2061979434 @default.
- W3049029268 cites W2062384274 @default.
- W3049029268 cites W2062657849 @default.
- W3049029268 cites W2062726623 @default.
- W3049029268 cites W2065210378 @default.
- W3049029268 cites W2068221996 @default.
- W3049029268 cites W2079575303 @default.
- W3049029268 cites W2083357530 @default.
- W3049029268 cites W2086079078 @default.
- W3049029268 cites W2089011844 @default.
- W3049029268 cites W2092433290 @default.
- W3049029268 cites W2092467660 @default.
- W3049029268 cites W2092806956 @default.
- W3049029268 cites W2095145874 @default.
- W3049029268 cites W2101365155 @default.
- W3049029268 cites W2116015430 @default.
- W3049029268 cites W2156555987 @default.
- W3049029268 cites W2165669645 @default.
- W3049029268 cites W2323333461 @default.
- W3049029268 cites W2329324873 @default.
- W3049029268 cites W2402680419 @default.
- W3049029268 cites W2413035156 @default.
- W3049029268 cites W2413991229 @default.
- W3049029268 cites W2514083532 @default.
- W3049029268 cites W2514331260 @default.
- W3049029268 cites W2560803099 @default.
- W3049029268 cites W2609607367 @default.
- W3049029268 cites W2742190693 @default.
- W3049029268 cites W2744515607 @default.
- W3049029268 cites W2759633738 @default.
- W3049029268 cites W2767645742 @default.
- W3049029268 cites W2773025441 @default.
- W3049029268 cites W2794204688 @default.
- W3049029268 cites W2805864058 @default.
- W3049029268 cites W2809644904 @default.
- W3049029268 cites W2905353061 @default.
- W3049029268 cites W2944342612 @default.
- W3049029268 cites W2946163655 @default.
- W3049029268 cites W2946825364 @default.
- W3049029268 cites W2954488016 @default.
- W3049029268 cites W2996011646 @default.
- W3049029268 cites W3007973025 @default.