FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049061707> ?p ?o ?g. }

• W3049061707 abstract "Abstract How stromal cells fill voids in wounded tissue remains one of the most fundamental questions in regenerative medicine. Fibroblasts are known to fill voids by depositing extracellular matrix (ECM) proteins while migrating towards the wound site; however, their ability to adopt an epithelial-like purse-string behaviour remains unexplored. Here, we fabricated an artificial wound with a deep void space to investigate fibroblasts’ behaviour during gap closure. We found that fibroblasts can form a free-standing bridge on deep microvoids and consequently close the void through the purse-string contraction, which was previously believed to be exclusively an epithelial wound closure mechanism. The results also revealed that the fibroblast gap closure in our fabricated 3D artificial wound depends on myosin II-mediated contractility and intercellular adherent junctions. Our study reveals that stromal cells can gain the structural features of epithelial cells, namely, intercellular contractile rings, to fulfil their functions under the specific microenvironmental conditions of tissue repair. Furthermore, fibroblasts can close artificial wounds with gap widths up to 300 μm, approximately twice as large as the critical epithelial gap closure size on non-adherent substrates. Fibroblasts exhibited a zip-up gap closure mechanism with a geometrical size effect. These findings reveal a new mechanism for gap closure by stromal cells during wound healing and pave a way to groundbreaking therapeutic strategies for tissue repair." @default.
• W3049061707 created "2020-08-21" @default.
• W3049061707 creator A5002494133 @default.
• W3049061707 creator A5009730469 @default.
• W3049061707 creator A5016243916 @default.
• W3049061707 creator A5042842813 @default.
• W3049061707 creator A5054458658 @default.
• W3049061707 creator A5065602591 @default.
• W3049061707 creator A5068964064 @default.
• W3049061707 creator A5081412330 @default.
• W3049061707 date "2020-08-15" @default.
• W3049061707 modified "2023-10-17" @default.
• W3049061707 title "Fibroblasts close a void in free space by a purse-string mechanism" @default.
• W3049061707 cites W1972081276 @default.
• W3049061707 cites W1981044612 @default.
• W3049061707 cites W1987918352 @default.
• W3049061707 cites W1989130793 @default.
• W3049061707 cites W2020472510 @default.
• W3049061707 cites W2023438419 @default.
• W3049061707 cites W2024781278 @default.
• W3049061707 cites W2050787387 @default.
• W3049061707 cites W2063538689 @default.
• W3049061707 cites W2068147631 @default.
• W3049061707 cites W2071236628 @default.
• W3049061707 cites W2075111970 @default.
• W3049061707 cites W2076394578 @default.
• W3049061707 cites W2078958131 @default.
• W3049061707 cites W2088064895 @default.
• W3049061707 cites W2094098398 @default.
• W3049061707 cites W2101281572 @default.
• W3049061707 cites W2101610294 @default.
• W3049061707 cites W2122265366 @default.
• W3049061707 cites W2144537799 @default.
• W3049061707 cites W2162804077 @default.
• W3049061707 cites W2170733892 @default.
• W3049061707 cites W2171424307 @default.
• W3049061707 cites W2297776087 @default.
• W3049061707 cites W2483359251 @default.
• W3049061707 cites W2577556668 @default.
• W3049061707 cites W2784479902 @default.
• W3049061707 cites W2898657218 @default.
• W3049061707 cites W2947534931 @default.
• W3049061707 cites W2953171652 @default.
• W3049061707 cites W3014726220 @default.
• W3049061707 cites W323560931 @default.
• W3049061707 cites W856260254 @default.
• W3049061707 doi "https://doi.org/10.1101/2020.08.15.250811" @default.
• W3049061707 hasPublicationYear "2020" @default.
• W3049061707 type Work @default.
• W3049061707 sameAs 3049061707 @default.
• W3049061707 citedByCount "2" @default.
• W3049061707 countsByYear W30490617072021 @default.
• W3049061707 countsByYear W30490617072022 @default.
• W3049061707 crossrefType "posted-content" @default.
• W3049061707 hasAuthorship W3049061707A5002494133 @default.
• W3049061707 hasAuthorship W3049061707A5009730469 @default.
• W3049061707 hasAuthorship W3049061707A5016243916 @default.
• W3049061707 hasAuthorship W3049061707A5042842813 @default.
• W3049061707 hasAuthorship W3049061707A5054458658 @default.
• W3049061707 hasAuthorship W3049061707A5065602591 @default.
• W3049061707 hasAuthorship W3049061707A5068964064 @default.
• W3049061707 hasAuthorship W3049061707A5081412330 @default.
• W3049061707 hasBestOaLocation W30490617071 @default.
• W3049061707 hasConcept C105702510 @default.
• W3049061707 hasConcept C12554922 @default.
• W3049061707 hasConcept C158157758 @default.
• W3049061707 hasConcept C16930146 @default.
• W3049061707 hasConcept C185592680 @default.
• W3049061707 hasConcept C189165786 @default.
• W3049061707 hasConcept C203014093 @default.
• W3049061707 hasConcept C2780269544 @default.
• W3049061707 hasConcept C2780381497 @default.
• W3049061707 hasConcept C2993873987 @default.
• W3049061707 hasConcept C502942594 @default.
• W3049061707 hasConcept C54355233 @default.
• W3049061707 hasConcept C79879829 @default.
• W3049061707 hasConcept C81885089 @default.
• W3049061707 hasConcept C86803240 @default.
• W3049061707 hasConcept C95444343 @default.
• W3049061707 hasConceptScore W3049061707C105702510 @default.
• W3049061707 hasConceptScore W3049061707C12554922 @default.
• W3049061707 hasConceptScore W3049061707C158157758 @default.
• W3049061707 hasConceptScore W3049061707C16930146 @default.
• W3049061707 hasConceptScore W3049061707C185592680 @default.
• W3049061707 hasConceptScore W3049061707C189165786 @default.
• W3049061707 hasConceptScore W3049061707C203014093 @default.
• W3049061707 hasConceptScore W3049061707C2780269544 @default.
• W3049061707 hasConceptScore W3049061707C2780381497 @default.
• W3049061707 hasConceptScore W3049061707C2993873987 @default.
• W3049061707 hasConceptScore W3049061707C502942594 @default.
• W3049061707 hasConceptScore W3049061707C54355233 @default.
• W3049061707 hasConceptScore W3049061707C79879829 @default.
• W3049061707 hasConceptScore W3049061707C81885089 @default.
• W3049061707 hasConceptScore W3049061707C86803240 @default.
• W3049061707 hasConceptScore W3049061707C95444343 @default.
• W3049061707 hasLocation W30490617071 @default.
• W3049061707 hasLocation W30490617072 @default.
• W3049061707 hasOpenAccess W3049061707 @default.
• W3049061707 hasPrimaryLocation W30490617071 @default.
• W3049061707 hasRelatedWork W11047703 @default.

• next