Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049067609> ?p ?o ?g. }
- W3049067609 endingPage "572" @default.
- W3049067609 startingPage "561" @default.
- W3049067609 abstract "Abstract Extracellular vesicles (EVs) are small reservoirs of different molecules and important mediators of cell-to-cell communication. As putative vehicles of misfolded protein propagation between cells, they have drawn substantial attention in the field of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Moreover, exosome-mediated non-coding RNA delivery may play a crucial role in ALS, given the relevance of RNA homeostasis in disease pathogenesis. Since EVs can enter the systemic circulation and are easily detectable in patients’ biological fluids, they have generated broad interest both as diagnostic and prognostic biomarkers and as valuable tools in understanding disease pathogenesis. Here, after a brief introduction on biogenesis and functions of EVs, we aim to investigate their role in neurodegenerative disorders, especially ALS. Specifically, we focus on the main findings supporting EV-mediated protein and RNA transmission in ALS in vitro and in vivo models. Then, we provide an overview of clinical applications of EVs, summarizing the most relevant studies able to detect EVs in blood and cerebrospinal fluid (CSF) of ALS patients, underlying their potential use in aiding diagnosis and prognosis. Finally, we explore the therapeutic applications of EVs in ALS, either as targets or as vehicles of proteins, nucleic acids and molecular drugs." @default.
- W3049067609 created "2020-08-21" @default.
- W3049067609 creator A5032993233 @default.
- W3049067609 creator A5038271133 @default.
- W3049067609 creator A5060263136 @default.
- W3049067609 creator A5076321492 @default.
- W3049067609 date "2020-08-16" @default.
- W3049067609 modified "2023-10-17" @default.
- W3049067609 title "Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers" @default.
- W3049067609 cites W1505019802 @default.
- W3049067609 cites W1877686344 @default.
- W3049067609 cites W1892074666 @default.
- W3049067609 cites W1910374374 @default.
- W3049067609 cites W1963767682 @default.
- W3049067609 cites W1966202673 @default.
- W3049067609 cites W1967069915 @default.
- W3049067609 cites W1977789448 @default.
- W3049067609 cites W1984538960 @default.
- W3049067609 cites W1985458075 @default.
- W3049067609 cites W1990597414 @default.
- W3049067609 cites W1991208268 @default.
- W3049067609 cites W1994195335 @default.
- W3049067609 cites W2003618511 @default.
- W3049067609 cites W2007106590 @default.
- W3049067609 cites W2018398216 @default.
- W3049067609 cites W2032355167 @default.
- W3049067609 cites W2032706649 @default.
- W3049067609 cites W2047139561 @default.
- W3049067609 cites W2047159195 @default.
- W3049067609 cites W2055313665 @default.
- W3049067609 cites W2062890651 @default.
- W3049067609 cites W2063198655 @default.
- W3049067609 cites W2065236536 @default.
- W3049067609 cites W2067013656 @default.
- W3049067609 cites W2068966740 @default.
- W3049067609 cites W2077047479 @default.
- W3049067609 cites W2078417042 @default.
- W3049067609 cites W2084469782 @default.
- W3049067609 cites W2086233696 @default.
- W3049067609 cites W2088483634 @default.
- W3049067609 cites W2097289714 @default.
- W3049067609 cites W2108191354 @default.
- W3049067609 cites W2109298880 @default.
- W3049067609 cites W2122866775 @default.
- W3049067609 cites W2130512072 @default.
- W3049067609 cites W2133133371 @default.
- W3049067609 cites W2134921841 @default.
- W3049067609 cites W2148050305 @default.
- W3049067609 cites W2157194244 @default.
- W3049067609 cites W2157252269 @default.
- W3049067609 cites W2169977305 @default.
- W3049067609 cites W2170087857 @default.
- W3049067609 cites W2174491776 @default.
- W3049067609 cites W2190404250 @default.
- W3049067609 cites W2204571250 @default.
- W3049067609 cites W2265559997 @default.
- W3049067609 cites W2276108155 @default.
- W3049067609 cites W2300507818 @default.
- W3049067609 cites W2325622993 @default.
- W3049067609 cites W2350344017 @default.
- W3049067609 cites W2506720562 @default.
- W3049067609 cites W2520511021 @default.
- W3049067609 cites W2524787240 @default.
- W3049067609 cites W2531459060 @default.
- W3049067609 cites W2574784626 @default.
- W3049067609 cites W2583401467 @default.
- W3049067609 cites W2608697804 @default.
- W3049067609 cites W2615003101 @default.
- W3049067609 cites W2624248893 @default.
- W3049067609 cites W2625301816 @default.
- W3049067609 cites W2754129305 @default.
- W3049067609 cites W2771557629 @default.
- W3049067609 cites W2781721887 @default.
- W3049067609 cites W2783774884 @default.
- W3049067609 cites W2790872584 @default.
- W3049067609 cites W2791750866 @default.
- W3049067609 cites W2796190709 @default.
- W3049067609 cites W2796631501 @default.
- W3049067609 cites W2810988246 @default.
- W3049067609 cites W2897111393 @default.
- W3049067609 cites W2904034429 @default.
- W3049067609 cites W2908859023 @default.
- W3049067609 cites W2909115119 @default.
- W3049067609 cites W2911503339 @default.
- W3049067609 cites W2937986807 @default.
- W3049067609 cites W2940731102 @default.
- W3049067609 cites W2948661768 @default.
- W3049067609 cites W2955933464 @default.
- W3049067609 cites W2958789035 @default.
- W3049067609 cites W2969791528 @default.
- W3049067609 cites W2973205926 @default.
- W3049067609 cites W2980841794 @default.
- W3049067609 cites W2981903289 @default.
- W3049067609 cites W3010978707 @default.
- W3049067609 cites W3011349305 @default.
- W3049067609 cites W3012646333 @default.
- W3049067609 cites W3015210584 @default.
- W3049067609 cites W3026155598 @default.