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• W3049069035 abstract "Nutrient starvation is a common phenomenon that occurs during T cell activation. Upon pathogen infection, large amounts of immune cells migrate to infection sites, and antigen-specific T cells are activated; this is followed by rapid proliferation through clonal expansion. The dramatic expansion of cells will commonly lead to nutrient shortage. Cellular autophagy is often upregulated as a way to sustain the body's energy requirements. During infection, human immunodeficiency virus (HIV) co-opts a series of host cell metabolic pathways for replication. Several HIV proteins, such as Env, Nef, and Vpr, have already been reported as being involved in autophagy-related processes. In this report, we identified that the HIV p17 protein acts as a major factor in suppressing the autophagic process in T cells, especially under glucose starvation condition. HIV p17 interacts with Obg-like ATPase 1 (OLA1) and disrupts OLA1-glycogen synthase kinase-3 beta (GSK3β) complex, leading to GSK3β hyperactivation. Consequently, a prior proliferation of HIV-infected T cells under glucose starvation will occur. The inhibition of autophagy also aids HIV replication by antagonizing the antiviral effect of autophagy. Our study shows a new cellular pathway that HIV can hijack for viral spreading by a prior proliferation of HIV-loaded T cells and may provide new therapeutic targets for acquired immunodeficiency syndrome intervention." @default.
• W3049069035 created "2020-08-21" @default.
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• W3049069035 date "2020-08-21" @default.
• W3049069035 modified "2023-10-12" @default.
• W3049069035 title "HIV p17 enhances T cell proliferation by suppressing autophagy through the p17‐OLA1‐GSK3β axis under nutrient starvation" @default.
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• W3049069035 doi "https://doi.org/10.1002/jmv.26423" @default.
• W3049069035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32790080" @default.
• W3049069035 hasPublicationYear "2020" @default.
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