FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049142003> ?p ?o ?g. }

• W3049142003 endingPage "1177" @default.
• W3049142003 startingPage "1169" @default.
• W3049142003 abstract "Purpose Iodine-131-labelled meta-iodobenzylguanidine (131I-mIBG) and lutetium-177-labelled DOTATATE (177Lu-DOTATATE) are used for molecular radiotherapy of metastatic neuroblastoma. These are taken up by the noradrenaline transporter (NAT) and the somatostatin receptor subtype 2 (SSTR-2), respectively. Scintigraphy of iodine-123-labelled meta-iodobenzylguanidine (123I-mIBG) and gallium-68 DOTATATE (68Ga-DOTATATE) PET are used to select patients for therapy. These demonstrate the extent and location of tumour, and avidity of uptake by cells expressing NAT and SSTR-2, respectively. This study compared the similarities and differences in the anatomical distribution of these two imaging biomarkers in an unselected series of patients with metastatic neuroblastoma undergoing assessment for molecular radiotherapy. Methods Paired whole-body planar 123I-mIBG views and 68Ga-DOTATATE maximum intensity projection PET scans of metastatic neuroblastoma patients were visually compared. The disease extent was assessed by a semiquantitative scoring method. Results Paired scans from 42 patients were reviewed. 68Ga-DOTATATE scans were positive in all patients, 123I-mIBG scans were negative in two. In two patients, there was a mismatch, with some lesions identified only on the 123I-mIBG scan, and others visible only on the 68Ga-DOTATATE scan. Conclusion 68Ga-DOTATATE and 123I-mIBG scans yield complementary information. For a more comprehensive assessment, consideration could be given to the use of both 123I-mIBG and 68Ga-DOTATATE imaging scans. Because of the heterogeneity of distribution of molecular targets revealed by these techniques, a combination of both 131I-mIBG and 177Lu-DOTATATE molecular radiotherapy may possibly be more effective than either alone." @default.
• W3049142003 created "2020-08-21" @default.
• W3049142003 creator A5006473672 @default.
• W3049142003 creator A5006682056 @default.
• W3049142003 creator A5026912207 @default.
• W3049142003 creator A5036658495 @default.
• W3049142003 creator A5050318097 @default.
• W3049142003 creator A5064732539 @default.
• W3049142003 creator A5078551909 @default.
• W3049142003 date "2020-08-10" @default.
• W3049142003 modified "2023-10-14" @default.
• W3049142003 title "68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy" @default.
• W3049142003 cites W1998858645 @default.
• W3049142003 cites W2000506699 @default.
• W3049142003 cites W2008015692 @default.
• W3049142003 cites W2017646567 @default.
• W3049142003 cites W2017846301 @default.
• W3049142003 cites W2035594058 @default.
• W3049142003 cites W2037773575 @default.
• W3049142003 cites W2047172426 @default.
• W3049142003 cites W2049930466 @default.
• W3049142003 cites W2052959198 @default.
• W3049142003 cites W2056762938 @default.
• W3049142003 cites W2058780072 @default.
• W3049142003 cites W2075503943 @default.
• W3049142003 cites W2080622954 @default.
• W3049142003 cites W2087589038 @default.
• W3049142003 cites W2101362713 @default.
• W3049142003 cites W2110103490 @default.
• W3049142003 cites W2112838511 @default.
• W3049142003 cites W2122286507 @default.
• W3049142003 cites W2126218428 @default.
• W3049142003 cites W2134257528 @default.
• W3049142003 cites W2152420890 @default.
• W3049142003 cites W2156920235 @default.
• W3049142003 cites W2211232874 @default.
• W3049142003 cites W2213548494 @default.
• W3049142003 cites W2226076446 @default.
• W3049142003 cites W2343075275 @default.
• W3049142003 cites W2400681987 @default.
• W3049142003 cites W2407688877 @default.
• W3049142003 cites W2523575310 @default.
• W3049142003 cites W2532265787 @default.
• W3049142003 cites W2573369749 @default.
• W3049142003 cites W2592061165 @default.
• W3049142003 cites W2611071372 @default.
• W3049142003 cites W2766322324 @default.
• W3049142003 cites W2774773003 @default.
• W3049142003 cites W2792153970 @default.
• W3049142003 cites W2810818134 @default.
• W3049142003 cites W3004101682 @default.
• W3049142003 cites W3011732986 @default.
• W3049142003 cites W3027165574 @default.
• W3049142003 doi "https://doi.org/10.1097/mnm.0000000000001265" @default.
• W3049142003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32796449" @default.
• W3049142003 hasPublicationYear "2020" @default.
• W3049142003 type Work @default.
• W3049142003 sameAs 3049142003 @default.
• W3049142003 citedByCount "20" @default.
• W3049142003 countsByYear W30491420032020 @default.
• W3049142003 countsByYear W30491420032021 @default.
• W3049142003 countsByYear W30491420032022 @default.
• W3049142003 countsByYear W30491420032023 @default.
• W3049142003 crossrefType "journal-article" @default.
• W3049142003 hasAuthorship W3049142003A5006473672 @default.
• W3049142003 hasAuthorship W3049142003A5006682056 @default.
• W3049142003 hasAuthorship W3049142003A5026912207 @default.
• W3049142003 hasAuthorship W3049142003A5036658495 @default.
• W3049142003 hasAuthorship W3049142003A5050318097 @default.
• W3049142003 hasAuthorship W3049142003A5064732539 @default.
• W3049142003 hasAuthorship W3049142003A5078551909 @default.
• W3049142003 hasConcept C126322002 @default.
• W3049142003 hasConcept C126838900 @default.
• W3049142003 hasConcept C136339569 @default.
• W3049142003 hasConcept C143998085 @default.
• W3049142003 hasConcept C150903083 @default.
• W3049142003 hasConcept C207001950 @default.
• W3049142003 hasConcept C2776297358 @default.
• W3049142003 hasConcept C2776715637 @default.
• W3049142003 hasConcept C2779066768 @default.
• W3049142003 hasConcept C2989005 @default.
• W3049142003 hasConcept C2993559085 @default.
• W3049142003 hasConcept C509974204 @default.
• W3049142003 hasConcept C54355233 @default.
• W3049142003 hasConcept C71924100 @default.
• W3049142003 hasConcept C80115893 @default.
• W3049142003 hasConcept C81885089 @default.
• W3049142003 hasConcept C86803240 @default.
• W3049142003 hasConceptScore W3049142003C126322002 @default.
• W3049142003 hasConceptScore W3049142003C126838900 @default.
• W3049142003 hasConceptScore W3049142003C136339569 @default.
• W3049142003 hasConceptScore W3049142003C143998085 @default.
• W3049142003 hasConceptScore W3049142003C150903083 @default.
• W3049142003 hasConceptScore W3049142003C207001950 @default.
• W3049142003 hasConceptScore W3049142003C2776297358 @default.
• W3049142003 hasConceptScore W3049142003C2776715637 @default.
• W3049142003 hasConceptScore W3049142003C2779066768 @default.
• W3049142003 hasConceptScore W3049142003C2989005 @default.

• next