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- W3049205051 abstract "Leptospirosis is a devastating zoonotic disease affecting people and animals across the globe. Pathogenic leptospires are excreted in urine of reservoir hosts which directly or indirectly leads to continued disease transmission, via contact with mucous membranes or a breach of the skin barrier of another host. Human fatalities approach 60,000 deaths per annum; though most vertebrates are susceptible to leptospirosis, complex interactions between host species and serovars of Leptospira can yield disease phenotypes that vary from asymptomatic shedding in reservoir hosts, to multi-organ failure in incidental hosts. Clinical symptoms of acute leptospirosis reflect the diverse range of pathogenic species and serovars that cause infection, the level of exposure, and the relationship of the pathogen with the given host. However, in all cases, pathogenic Leptospira are excreted into the environment via urine from reservoir hosts which are uniformly recognized as asymptomatic carriers. Therefore, the reservoir host serves as the cornerstone of persistent disease transmission. Although bacterin vaccines can be used to abate renal carriage and excretion in domestic animal species, there is an urgent need to advance our understanding of immune-mediated host-pathogen interactions that facilitate persistent asymptomatic carriage. This review summarizes understanding of host-pathogen interactions in the reservoir host and prioritizes research to unravel mechanisms that allow for colonization but not destruction of the host. This information is required to understand, and ultimately control, the transmission of pathogenic Leptospira." @default.
- W3049205051 created "2020-08-21" @default.
- W3049205051 creator A5071266417 @default.
- W3049205051 creator A5075983763 @default.
- W3049205051 date "2020-08-14" @default.
- W3049205051 modified "2023-09-30" @default.
- W3049205051 title "Investigating the Immunological and Biological Equilibrium of Reservoir Hosts and Pathogenic Leptospira: Balancing the Solution to an Acute Problem?" @default.
- W3049205051 cites W135229234 @default.
- W3049205051 cites W146489644 @default.
- W3049205051 cites W149836029 @default.
- W3049205051 cites W1522613534 @default.
- W3049205051 cites W1669424064 @default.
- W3049205051 cites W1868048390 @default.
- W3049205051 cites W1927641937 @default.
- W3049205051 cites W1940668979 @default.
- W3049205051 cites W1946825159 @default.
- W3049205051 cites W1948094720 @default.
- W3049205051 cites W1968693613 @default.
- W3049205051 cites W1971593420 @default.
- W3049205051 cites W1971808245 @default.
- W3049205051 cites W1971858159 @default.
- W3049205051 cites W1972702677 @default.
- W3049205051 cites W1975769885 @default.
- W3049205051 cites W1976643367 @default.
- W3049205051 cites W1978355031 @default.
- W3049205051 cites W1978821380 @default.
- W3049205051 cites W1981015058 @default.
- W3049205051 cites W1982583555 @default.
- W3049205051 cites W1985079071 @default.
- W3049205051 cites W1986163501 @default.
- W3049205051 cites W1987645055 @default.
- W3049205051 cites W1988566610 @default.
- W3049205051 cites W1991929467 @default.
- W3049205051 cites W1999884972 @default.
- W3049205051 cites W2006554328 @default.
- W3049205051 cites W2008633757 @default.
- W3049205051 cites W2010020652 @default.
- W3049205051 cites W2014562445 @default.
- W3049205051 cites W2028485921 @default.
- W3049205051 cites W2030358658 @default.
- W3049205051 cites W2032329628 @default.
- W3049205051 cites W2032415057 @default.
- W3049205051 cites W2033026074 @default.
- W3049205051 cites W2033375819 @default.
- W3049205051 cites W2040343836 @default.
- W3049205051 cites W2042016124 @default.
- W3049205051 cites W2043490252 @default.
- W3049205051 cites W2045349072 @default.
- W3049205051 cites W2047905751 @default.
- W3049205051 cites W2048791516 @default.
- W3049205051 cites W2049512199 @default.
- W3049205051 cites W2051836046 @default.
- W3049205051 cites W2058529735 @default.
- W3049205051 cites W2059592439 @default.
- W3049205051 cites W2059709898 @default.
- W3049205051 cites W2060639254 @default.
- W3049205051 cites W2062708463 @default.
- W3049205051 cites W2063798039 @default.
- W3049205051 cites W2065680164 @default.
- W3049205051 cites W2069394593 @default.
- W3049205051 cites W2070093265 @default.
- W3049205051 cites W2073228815 @default.
- W3049205051 cites W2073832068 @default.
- W3049205051 cites W2079783142 @default.
- W3049205051 cites W2083103767 @default.
- W3049205051 cites W2085992091 @default.
- W3049205051 cites W2086610402 @default.
- W3049205051 cites W2093029664 @default.
- W3049205051 cites W2094332869 @default.
- W3049205051 cites W2097077388 @default.
- W3049205051 cites W2097460680 @default.
- W3049205051 cites W2097970334 @default.
- W3049205051 cites W2099354660 @default.
- W3049205051 cites W2099416536 @default.
- W3049205051 cites W2099800301 @default.
- W3049205051 cites W2104400551 @default.
- W3049205051 cites W2104617153 @default.
- W3049205051 cites W2105461608 @default.
- W3049205051 cites W2105844941 @default.
- W3049205051 cites W2106228222 @default.
- W3049205051 cites W2107418731 @default.
- W3049205051 cites W2108222796 @default.
- W3049205051 cites W2109324208 @default.
- W3049205051 cites W2110146368 @default.
- W3049205051 cites W2110454331 @default.
- W3049205051 cites W2111631783 @default.
- W3049205051 cites W2112183228 @default.
- W3049205051 cites W2113238521 @default.
- W3049205051 cites W2119058849 @default.
- W3049205051 cites W2120076130 @default.
- W3049205051 cites W2122663726 @default.
- W3049205051 cites W2140823624 @default.
- W3049205051 cites W2141974683 @default.
- W3049205051 cites W2143427594 @default.
- W3049205051 cites W2144691829 @default.
- W3049205051 cites W2144728133 @default.
- W3049205051 cites W2144888379 @default.
- W3049205051 cites W2148002467 @default.
- W3049205051 cites W2151855816 @default.
- W3049205051 cites W2152667105 @default.