FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049220110> ?p ?o ?g. }

• W3049220110 abstract "Graphene, known as black gold, has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity. However, the immunotoxicity of GO has not been fully elucidated. In this work, we used DC2.4 cell line to investigate the in vitro immunotoxicity of two types of GO, mono-layer GO (mono-GO) and multi-layer GO (multi- GO). We found that mono-GO had less effect on cell viability than multi-GO, but both mono-GO and multi-GO significantly induced the generation of ROS in DC2.4 cells. Interestingly, mono-GO caused DC2.4 cells to aggregate, thus changed the cell morphology significantly. However, no similar influence occurred for multi-GO. In addition, the results showed that these two GOs obviously enhance the release of TNF-α by DC2.4 cells with and without LPS stimulation. GO did not affect the level of IL-6 released from DC2.4 cells, but multi-GO promoted the release of IL-6 while mono-GO inhibited the production of IL-6 when cells were in response to LPS stimulation. Whole-transcriptome sequencing analysis found some immune-related differentially expressed genes including H2-DMb1, Ncbp3, Oas2, Men1, Fas, Cd320, Cd244, and Tinagl1 which are engaged in the immune system process. These results suggested that both mono-GO and multi-GO are immunotoxic to DC2.4 cells, which provides important basis for subsequent biological and clinical medical applications." @default.
• W3049220110 created "2020-08-21" @default.
• W3049220110 creator A5017384752 @default.
• W3049220110 creator A5025910531 @default.
• W3049220110 creator A5027475930 @default.
• W3049220110 creator A5030119740 @default.
• W3049220110 creator A5030547574 @default.
• W3049220110 creator A5044163815 @default.
• W3049220110 creator A5080154928 @default.
• W3049220110 creator A5083221084 @default.
• W3049220110 creator A5087264224 @default.
• W3049220110 date "2020-08-17" @default.
• W3049220110 modified "2023-10-16" @default.
• W3049220110 title "Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide" @default.
• W3049220110 cites W1819994755 @default.
• W3049220110 cites W1990546100 @default.
• W3049220110 cites W1992177385 @default.
• W3049220110 cites W1995586746 @default.
• W3049220110 cites W2012588499 @default.
• W3049220110 cites W2018559315 @default.
• W3049220110 cites W2052974669 @default.
• W3049220110 cites W2058122340 @default.
• W3049220110 cites W2059350595 @default.
• W3049220110 cites W2072041955 @default.
• W3049220110 cites W2088913828 @default.
• W3049220110 cites W2143950817 @default.
• W3049220110 cites W2239629610 @default.
• W3049220110 cites W2328299947 @default.
• W3049220110 cites W2345773910 @default.
• W3049220110 cites W2526448439 @default.
• W3049220110 cites W2542924420 @default.
• W3049220110 cites W2589601906 @default.
• W3049220110 cites W2597188946 @default.
• W3049220110 cites W2606820016 @default.
• W3049220110 cites W2737364956 @default.
• W3049220110 cites W2772416957 @default.
• W3049220110 cites W2773653178 @default.
• W3049220110 cites W2782056794 @default.
• W3049220110 cites W2786389763 @default.
• W3049220110 cites W2789790571 @default.
• W3049220110 cites W2796749416 @default.
• W3049220110 cites W2797517281 @default.
• W3049220110 cites W2801732475 @default.
• W3049220110 cites W2804860155 @default.
• W3049220110 cites W2805167315 @default.
• W3049220110 cites W2807278179 @default.
• W3049220110 cites W2808210137 @default.
• W3049220110 cites W2886680800 @default.
• W3049220110 cites W2900993832 @default.
• W3049220110 cites W2903455161 @default.
• W3049220110 cites W2906573949 @default.
• W3049220110 cites W2910949153 @default.
• W3049220110 cites W2912285398 @default.
• W3049220110 cites W2912352630 @default.
• W3049220110 cites W2949688325 @default.
• W3049220110 cites W2953477834 @default.
• W3049220110 cites W2993405837 @default.
• W3049220110 cites W2999204854 @default.
• W3049220110 cites W3009151075 @default.
• W3049220110 doi "https://doi.org/10.3389/fphar.2020.01206" @default.
• W3049220110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7461934" @default.
• W3049220110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32973494" @default.
• W3049220110 hasPublicationYear "2020" @default.
• W3049220110 type Work @default.
• W3049220110 sameAs 3049220110 @default.
• W3049220110 citedByCount "20" @default.
• W3049220110 countsByYear W30492201102021 @default.
• W3049220110 countsByYear W30492201102022 @default.
• W3049220110 countsByYear W30492201102023 @default.
• W3049220110 crossrefType "journal-article" @default.
• W3049220110 hasAuthorship W3049220110A5017384752 @default.
• W3049220110 hasAuthorship W3049220110A5025910531 @default.
• W3049220110 hasAuthorship W3049220110A5027475930 @default.
• W3049220110 hasAuthorship W3049220110A5030119740 @default.
• W3049220110 hasAuthorship W3049220110A5030547574 @default.
• W3049220110 hasAuthorship W3049220110A5044163815 @default.
• W3049220110 hasAuthorship W3049220110A5080154928 @default.
• W3049220110 hasAuthorship W3049220110A5083221084 @default.
• W3049220110 hasAuthorship W3049220110A5087264224 @default.
• W3049220110 hasBestOaLocation W30492201101 @default.
• W3049220110 hasConcept C104317684 @default.
• W3049220110 hasConcept C109316439 @default.
• W3049220110 hasConcept C150194340 @default.
• W3049220110 hasConcept C162317418 @default.
• W3049220110 hasConcept C171250308 @default.
• W3049220110 hasConcept C185592680 @default.
• W3049220110 hasConcept C192562407 @default.
• W3049220110 hasConcept C202751555 @default.
• W3049220110 hasConcept C203014093 @default.
• W3049220110 hasConcept C30080830 @default.
• W3049220110 hasConcept C55493867 @default.
• W3049220110 hasConcept C86803240 @default.
• W3049220110 hasConcept C8891405 @default.
• W3049220110 hasConcept C95444343 @default.
• W3049220110 hasConceptScore W3049220110C104317684 @default.
• W3049220110 hasConceptScore W3049220110C109316439 @default.
• W3049220110 hasConceptScore W3049220110C150194340 @default.
• W3049220110 hasConceptScore W3049220110C162317418 @default.
• W3049220110 hasConceptScore W3049220110C171250308 @default.
• W3049220110 hasConceptScore W3049220110C185592680 @default.

• next