Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049273902> ?p ?o ?g. }
- W3049273902 endingPage "78" @default.
- W3049273902 startingPage "66" @default.
- W3049273902 abstract "Monocytes are circulating myeloid immune precursor cells that are generated in the bone marrow. Mature monocytes are released into the circulation and, in case of need, recruited to peripheral sites of inflammation to differentiate into monocyte-derived effector cells. In absence of overt inflammation, monocytes also extravasate into selected tissues, where they complement tissue-resident macrophage compartments. Adjustment of these homeostatic monocyte infiltrates to local environment is critical to maintain health, as best established for the intestine. Defined gene expression changes that differ between gut segments presumably help strike the fine balance between the crucial function of these monocyte-derived macrophages as tissue rheostats and their detrimental hyperactivation. Environmental factors that dictate local monocyte differentiation remain incompletely understood. Definition of the latter could aid our general understanding of in vivo monocyte functions and their relation to inflammatory disorders. In this review, we summarize recent advances in our understanding of monocyte subsets, their differentiation into tissue macrophages, and selected contributions of monocyte-derived cells to steady-state physiology. Moreover, we will discuss emerging evidence for an intriguing bifurcation of monocyte development in the bone marrow and potential functional implications. Emphasis will be given to points of controversies, but we will largely focus on the healthy organism. For a discussion of monocyte and macrophage contributions to inflammatory conditions, we refer the reader to other dedicated reviews." @default.
- W3049273902 created "2020-08-21" @default.
- W3049273902 creator A5030072900 @default.
- W3049273902 creator A5085718942 @default.
- W3049273902 date "2020-11-01" @default.
- W3049273902 modified "2023-10-11" @default.
- W3049273902 title "Plasticity of monocyte development and monocyte fates" @default.
- W3049273902 cites W1483521748 @default.
- W3049273902 cites W1507275598 @default.
- W3049273902 cites W1557119871 @default.
- W3049273902 cites W1723001059 @default.
- W3049273902 cites W1887681162 @default.
- W3049273902 cites W1954497589 @default.
- W3049273902 cites W1964875700 @default.
- W3049273902 cites W1966100182 @default.
- W3049273902 cites W1966272914 @default.
- W3049273902 cites W1974749956 @default.
- W3049273902 cites W1975463463 @default.
- W3049273902 cites W1976808796 @default.
- W3049273902 cites W1976933461 @default.
- W3049273902 cites W1977536320 @default.
- W3049273902 cites W1979292513 @default.
- W3049273902 cites W1979948289 @default.
- W3049273902 cites W1981858801 @default.
- W3049273902 cites W1985502949 @default.
- W3049273902 cites W1993603859 @default.
- W3049273902 cites W1995425644 @default.
- W3049273902 cites W1996345228 @default.
- W3049273902 cites W1997204455 @default.
- W3049273902 cites W2002703043 @default.
- W3049273902 cites W2003870922 @default.
- W3049273902 cites W2010484682 @default.
- W3049273902 cites W2022485121 @default.
- W3049273902 cites W2031603575 @default.
- W3049273902 cites W2034484954 @default.
- W3049273902 cites W2043659905 @default.
- W3049273902 cites W2043897018 @default.
- W3049273902 cites W2044216294 @default.
- W3049273902 cites W2045121415 @default.
- W3049273902 cites W2050988558 @default.
- W3049273902 cites W2054581136 @default.
- W3049273902 cites W2055736709 @default.
- W3049273902 cites W2062363040 @default.
- W3049273902 cites W2065639597 @default.
- W3049273902 cites W2067401763 @default.
- W3049273902 cites W2068714945 @default.
- W3049273902 cites W2078621117 @default.
- W3049273902 cites W2080844075 @default.
- W3049273902 cites W2083089709 @default.
- W3049273902 cites W2087101282 @default.
- W3049273902 cites W2090786449 @default.
- W3049273902 cites W2090927176 @default.
- W3049273902 cites W2094930641 @default.
- W3049273902 cites W2096179876 @default.
- W3049273902 cites W2098165912 @default.
- W3049273902 cites W2098954540 @default.
- W3049273902 cites W2102186747 @default.
- W3049273902 cites W2102628016 @default.
- W3049273902 cites W2106274007 @default.
- W3049273902 cites W2113594480 @default.
- W3049273902 cites W2116432220 @default.
- W3049273902 cites W2123480703 @default.
- W3049273902 cites W2126263479 @default.
- W3049273902 cites W2126811287 @default.
- W3049273902 cites W2126922170 @default.
- W3049273902 cites W2134254929 @default.
- W3049273902 cites W2135647797 @default.
- W3049273902 cites W2135703618 @default.
- W3049273902 cites W2141214625 @default.
- W3049273902 cites W2151362823 @default.
- W3049273902 cites W2153406260 @default.
- W3049273902 cites W2154697999 @default.
- W3049273902 cites W2159443316 @default.
- W3049273902 cites W2161057248 @default.
- W3049273902 cites W2163804088 @default.
- W3049273902 cites W2170625377 @default.
- W3049273902 cites W2171922871 @default.
- W3049273902 cites W2177432730 @default.
- W3049273902 cites W2201019342 @default.
- W3049273902 cites W2220698190 @default.
- W3049273902 cites W2232938630 @default.
- W3049273902 cites W2301038687 @default.
- W3049273902 cites W2336656712 @default.
- W3049273902 cites W2343063221 @default.
- W3049273902 cites W2398894736 @default.
- W3049273902 cites W2465917013 @default.
- W3049273902 cites W2468094059 @default.
- W3049273902 cites W2506892818 @default.
- W3049273902 cites W2512649632 @default.
- W3049273902 cites W2515872577 @default.
- W3049273902 cites W2515907404 @default.
- W3049273902 cites W2530903079 @default.
- W3049273902 cites W2537351581 @default.
- W3049273902 cites W2548678995 @default.
- W3049273902 cites W2561257582 @default.
- W3049273902 cites W2562980016 @default.
- W3049273902 cites W2585731231 @default.
- W3049273902 cites W2592213450 @default.