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- W3049277611 abstract "Abstract This chapter focuses on apomorphine therapy, a device-aided strategy in Parkinson's disease. Apomorphine is a nonnarcotic and nonspecific dopaminergic agonist (D1-like and D2-like receptors) indicated in the case of suboptimal therapeutic response to oral antiparkinsonian medication. Two approaches are possible—either as a rescue therapy with acute injections (pen) or as a continuous therapy (pump). The injections provide quick and reliable relief of off-periods. Apomorphine infusion is an effective treatment for fluctuations with a positive effect on nonmotor symptoms and quality of life. Adverse events are usually mild and preventable (local side effects), but they have to be carefully monitored throughout the treatment. Patient selection, long-term follow-up, multidisciplinary teams, and regularly renewed education are essential to ensure the success of apomorphine pump therapy. Despite its efficacy, apomorphine remains misused and underused worldwide. Alternative routes of administration and apomorphine derivatives are currently under investigation to improve adherence and expand apomorphine therapy." @default.
- W3049277611 created "2020-08-21" @default.
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- W3049277611 date "2020-01-01" @default.
- W3049277611 modified "2023-10-18" @default.
- W3049277611 title "Management with apomorphine in Parkinson's disease" @default.
- W3049277611 doi "https://doi.org/10.1016/b978-0-12-815946-0.00027-2" @default.
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