Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049277790> ?p ?o ?g. }
- W3049277790 endingPage "751" @default.
- W3049277790 startingPage "751" @default.
- W3049277790 abstract "Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms. The KEAP1/NRF2 signaling pathway mediates the environmental responses of squamous epithelial tissue. The unpredicted outcome of the Keap1-null mutation in mice allowed us to revisit the basic principle of the biological process of keratinization: sulfur metabolism establishes unparalleled cytoprotection in the body wall of terrestrial mammals. We summarize the recent understanding of the KEAP1/NRF2 signaling pathway, which is a thiol-based sensor-effector apparatus, with particular focuses on epidermal differentiation in the context of the gene-environment interaction, the structure/function principles involved in KEAP1/NRF2 signaling, lessons from mouse models, and their pathological implications. This synthesis may provide insights into keratinization, which provides physical insulation and constitutes an essential innate integumentary defense system." @default.
- W3049277790 created "2020-08-21" @default.
- W3049277790 creator A5063775696 @default.
- W3049277790 creator A5065459224 @default.
- W3049277790 creator A5071625723 @default.
- W3049277790 date "2020-08-14" @default.
- W3049277790 modified "2023-10-17" @default.
- W3049277790 title "The KEAP1/NRF2 Signaling Pathway in Keratinization" @default.
- W3049277790 cites W1488946076 @default.
- W3049277790 cites W1502681357 @default.
- W3049277790 cites W1513215086 @default.
- W3049277790 cites W1522843415 @default.
- W3049277790 cites W1533811499 @default.
- W3049277790 cites W1535590188 @default.
- W3049277790 cites W1561096292 @default.
- W3049277790 cites W1843397982 @default.
- W3049277790 cites W1911198412 @default.
- W3049277790 cites W1964995369 @default.
- W3049277790 cites W1965168699 @default.
- W3049277790 cites W1966417240 @default.
- W3049277790 cites W1967304777 @default.
- W3049277790 cites W1971705093 @default.
- W3049277790 cites W1971771465 @default.
- W3049277790 cites W1972549014 @default.
- W3049277790 cites W1973141016 @default.
- W3049277790 cites W1973606753 @default.
- W3049277790 cites W1973794733 @default.
- W3049277790 cites W1973882427 @default.
- W3049277790 cites W1974546855 @default.
- W3049277790 cites W1977736016 @default.
- W3049277790 cites W1980768491 @default.
- W3049277790 cites W1980960936 @default.
- W3049277790 cites W1983537894 @default.
- W3049277790 cites W1983743651 @default.
- W3049277790 cites W1984539685 @default.
- W3049277790 cites W1985385055 @default.
- W3049277790 cites W1987343382 @default.
- W3049277790 cites W1990598806 @default.
- W3049277790 cites W1991265255 @default.
- W3049277790 cites W1991631628 @default.
- W3049277790 cites W1993446519 @default.
- W3049277790 cites W1995815237 @default.
- W3049277790 cites W1998464125 @default.
- W3049277790 cites W1998560601 @default.
- W3049277790 cites W1999622095 @default.
- W3049277790 cites W1999872962 @default.
- W3049277790 cites W2000517600 @default.
- W3049277790 cites W2001000673 @default.
- W3049277790 cites W2004465286 @default.
- W3049277790 cites W2007105056 @default.
- W3049277790 cites W2012750958 @default.
- W3049277790 cites W2017609866 @default.
- W3049277790 cites W2022608661 @default.
- W3049277790 cites W2025269038 @default.
- W3049277790 cites W2027085316 @default.
- W3049277790 cites W2027409527 @default.
- W3049277790 cites W2027630408 @default.
- W3049277790 cites W2028536701 @default.
- W3049277790 cites W2030867249 @default.
- W3049277790 cites W2038612772 @default.
- W3049277790 cites W2040114786 @default.
- W3049277790 cites W2040408532 @default.
- W3049277790 cites W2040898650 @default.
- W3049277790 cites W2042433863 @default.
- W3049277790 cites W2050512725 @default.
- W3049277790 cites W2052472486 @default.
- W3049277790 cites W2052548231 @default.
- W3049277790 cites W2052899135 @default.
- W3049277790 cites W2053919910 @default.
- W3049277790 cites W2055568103 @default.
- W3049277790 cites W2057093225 @default.
- W3049277790 cites W2057653740 @default.
- W3049277790 cites W2060869794 @default.
- W3049277790 cites W2061903251 @default.
- W3049277790 cites W2064330613 @default.
- W3049277790 cites W2067018261 @default.
- W3049277790 cites W2068176013 @default.
- W3049277790 cites W2069190004 @default.
- W3049277790 cites W2070100227 @default.
- W3049277790 cites W2070909725 @default.
- W3049277790 cites W2071191421 @default.
- W3049277790 cites W2072392419 @default.
- W3049277790 cites W2074790526 @default.
- W3049277790 cites W2075495668 @default.
- W3049277790 cites W2076405456 @default.
- W3049277790 cites W2080435498 @default.
- W3049277790 cites W2080506742 @default.
- W3049277790 cites W2080952734 @default.
- W3049277790 cites W2081462999 @default.
- W3049277790 cites W2084364631 @default.
- W3049277790 cites W2086919233 @default.
- W3049277790 cites W2087551745 @default.
- W3049277790 cites W2090456761 @default.
- W3049277790 cites W2091004447 @default.
- W3049277790 cites W2092482659 @default.
- W3049277790 cites W2094661084 @default.
- W3049277790 cites W2094921802 @default.
- W3049277790 cites W2097634036 @default.