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- W3049277939 endingPage "5856" @default.
- W3049277939 startingPage "5856" @default.
- W3049277939 abstract "The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibility of the protein structure. Furthermore, CQ and HCQ also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed by nsp10/nsp14 and nsp10/nsp16. In particular, HCQ demonstrated a better energy binding with the examined targets compared to CQ, probably due to the hydrogen bonding of the hydroxyl group of HCQ with polar amino acid residues." @default.
- W3049277939 created "2020-08-21" @default.
- W3049277939 creator A5001034113 @default.
- W3049277939 creator A5030294968 @default.
- W3049277939 creator A5030378131 @default.
- W3049277939 creator A5057685383 @default.
- W3049277939 date "2020-08-14" @default.
- W3049277939 modified "2023-09-25" @default.
- W3049277939 title "New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine" @default.
- W3049277939 cites W1167592479 @default.
- W3049277939 cites W1764270605 @default.
- W3049277939 cites W1963514652 @default.
- W3049277939 cites W1963538378 @default.
- W3049277939 cites W1965669216 @default.
- W3049277939 cites W1969475526 @default.
- W3049277939 cites W1969740333 @default.
- W3049277939 cites W1969749985 @default.
- W3049277939 cites W1975475128 @default.
- W3049277939 cites W1976483167 @default.
- W3049277939 cites W1977929380 @default.
- W3049277939 cites W1979623919 @default.
- W3049277939 cites W1980892321 @default.
- W3049277939 cites W1994195919 @default.
- W3049277939 cites W1994542643 @default.
- W3049277939 cites W1997371510 @default.
- W3049277939 cites W2003702772 @default.
- W3049277939 cites W2006299881 @default.
- W3049277939 cites W2006405491 @default.
- W3049277939 cites W2007366380 @default.
- W3049277939 cites W2007473404 @default.
- W3049277939 cites W2009144324 @default.
- W3049277939 cites W2009398581 @default.
- W3049277939 cites W2010569965 @default.
- W3049277939 cites W2013257331 @default.
- W3049277939 cites W2018212701 @default.
- W3049277939 cites W2032024165 @default.
- W3049277939 cites W2032452247 @default.
- W3049277939 cites W2035687084 @default.
- W3049277939 cites W2037535298 @default.
- W3049277939 cites W2038767163 @default.
- W3049277939 cites W2045996885 @default.
- W3049277939 cites W2047742004 @default.
- W3049277939 cites W2051534962 @default.
- W3049277939 cites W2052108354 @default.
- W3049277939 cites W2062230852 @default.
- W3049277939 cites W2066018734 @default.
- W3049277939 cites W2069123478 @default.
- W3049277939 cites W2071761665 @default.
- W3049277939 cites W2084419984 @default.
- W3049277939 cites W2086842705 @default.
- W3049277939 cites W2086851905 @default.
- W3049277939 cites W2088933990 @default.
- W3049277939 cites W2090678891 @default.
- W3049277939 cites W2093427616 @default.
- W3049277939 cites W2093815354 @default.
- W3049277939 cites W2095807050 @default.
- W3049277939 cites W2099099776 @default.
- W3049277939 cites W2100165440 @default.
- W3049277939 cites W2100707762 @default.
- W3049277939 cites W2108226298 @default.
- W3049277939 cites W2109813678 @default.
- W3049277939 cites W2123222332 @default.
- W3049277939 cites W2126428749 @default.
- W3049277939 cites W2126912468 @default.
- W3049277939 cites W2128679305 @default.
- W3049277939 cites W2131341500 @default.
- W3049277939 cites W2136525664 @default.
- W3049277939 cites W2140943911 @default.
- W3049277939 cites W2144288821 @default.
- W3049277939 cites W2147993766 @default.
- W3049277939 cites W2148955224 @default.
- W3049277939 cites W2154792548 @default.
- W3049277939 cites W2154850912 @default.
- W3049277939 cites W2165740172 @default.
- W3049277939 cites W2332345235 @default.
- W3049277939 cites W2404280981 @default.
- W3049277939 cites W2404721671 @default.
- W3049277939 cites W2406377474 @default.
- W3049277939 cites W2409018787 @default.
- W3049277939 cites W2412447010 @default.
- W3049277939 cites W2415431679 @default.
- W3049277939 cites W241954630 @default.
- W3049277939 cites W2470646526 @default.
- W3049277939 cites W2519928122 @default.
- W3049277939 cites W2580356750 @default.
- W3049277939 cites W2626637404 @default.
- W3049277939 cites W2790185928 @default.
- W3049277939 cites W2803294153 @default.
- W3049277939 cites W2803748520 @default.
- W3049277939 cites W2943222525 @default.
- W3049277939 cites W2947642275 @default.
- W3049277939 cites W2963895440 @default.
- W3049277939 cites W2989884055 @default.
- W3049277939 cites W3000034834 @default.
- W3049277939 cites W3001897055 @default.
- W3049277939 cites W3005409321 @default.
- W3049277939 cites W3008874180 @default.
- W3049277939 cites W3009912996 @default.