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- W3049297770 endingPage "1908" @default.
- W3049297770 startingPage "1908" @default.
- W3049297770 abstract "The nuclear envelope (NE) consists of the inner and outer nuclear membranes (INM and ONM), and the nuclear pore complex (NPC), which penetrates the double membrane. ONM continues with the endoplasmic reticulum (ER). INM and NPC can interact with chromatin to regulate the genetic activities of the chromosome. Studies in the fission yeast Schizosaccharomyces pombe have contributed to understanding the molecular mechanisms underlying heterochromatin formation by the RNAi-mediated and histone deacetylase machineries. Recent studies have demonstrated that NE proteins modulate heterochromatin formation and functions through interactions with heterochromatic regions, including the pericentromeric and the sub-telomeric regions. In this review, we first introduce the molecular mechanisms underlying the heterochromatin formation and functions in fission yeast, and then summarize the NE proteins that play a role in anchoring heterochromatic regions and in modulating heterochromatin formation and functions, highlighting roles for a conserved INM protein, Lem2." @default.
- W3049297770 created "2020-08-21" @default.
- W3049297770 creator A5006137910 @default.
- W3049297770 creator A5037935644 @default.
- W3049297770 creator A5063961889 @default.
- W3049297770 creator A5065796724 @default.
- W3049297770 creator A5076833397 @default.
- W3049297770 date "2020-08-16" @default.
- W3049297770 modified "2023-10-14" @default.
- W3049297770 title "Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast" @default.
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