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- W3049319728 abstract "Abstract Background Scleroderma renal crisis is a condition that affects approximately 4–6% of patients with systemic sclerosis, especially with diffuse compromise. Clinical manifestations are variable, representing a diagnostic challenge. Objective The study aims to describe and analyze the different pharmacological treatments available for the management of scleroderma renal crisis. Materials and methods A systematic literature review was done based on observational studies and clinical trials about the treatment of scleroderma renal crisis, using monotherapy or combined therapy. The studies were identified using electronic scientific databases, including MEDLINE PUBMED and EMBASE, in English, published between January 1990 and August 2019. Results Eleven studies were included (ten observational studies and one open clinical trial). Of them, seven were cohorts, one case series, and two case–control studies. Overall, 1113 patients were included in the analyzed studies. All studies used angiotensin-converting enzyme inhibitors as exposition, case definition, and/or comparison in the clinical trial. Regarding the need for dialysis, approximately 53.9% of patients required it temporarily or permanently. Approximately 6–27% of patients required temporal dialysis, and 19–78% required permanent dialysis. One-year survival range was between 64 and 84%; two-year survival was between 53 and 74%; five-year survival between 40 and 90%, and finally ten–year survival between 35 and 47%. Conclusions Angiotensin-converting enzyme inhibitors continue to be the first line of treatment for scleroderma renal crisis by contributing to a decrease in short-term mortality. However, alternative therapeutic options are required as a high percentage of patients still require dialysis. Future clinical trials are necessary to assess the effectiveness and safety of different therapeutic options." @default.
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- W3049319728 date "2020-04-01" @default.
- W3049319728 modified "2023-10-18" @default.
- W3049319728 title "Pharmacological treatment of scleroderma renal crisis: A systematic literature review" @default.
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- W3049319728 doi "https://doi.org/10.1016/j.rcreue.2020.01.003" @default.
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