Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049403629> ?p ?o ?g. }
- W3049403629 abstract "Alzheimer's disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running behavior both early and late in disease progression in a novel dual Tg mouse model of AD. This mouse includes both amyloid and tau pathology through its cross with the J20 (hAPP) and P301L (Tau) parentage. Animals were given either lab water or water that had been supplemented with 10 ppm Zn. Wheel running was assessed through individually housing mice and measuring wheel-running activity in both the light and dark cycles. Dual Tg mice showed significantly less activity in the first part of the dark cycle than WT mice at both 3.5 and 7 months of age (p < 0.05). Dual Tg mice given Zn water showed less activity compared to dual Tg mice on lab water, tau mice on Zn water, or WT mice given either lab or Zn water (p < 0.05) at 7 months. Female mice in this study consistently showed higher activity compared to male mice in all groups whereas Zn led to reduced activity. Daily activity rhythm was altered in both the tau and dual Tg mice, and Zn impacted this alteration through effects on amyloid, tau, and through circadian pathways." @default.
- W3049403629 created "2020-08-21" @default.
- W3049403629 creator A5033954219 @default.
- W3049403629 creator A5042840503 @default.
- W3049403629 creator A5043653028 @default.
- W3049403629 creator A5089818985 @default.
- W3049403629 date "2020-08-14" @default.
- W3049403629 modified "2023-09-27" @default.
- W3049403629 title "Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD" @default.
- W3049403629 cites W1492580828 @default.
- W3049403629 cites W1512945168 @default.
- W3049403629 cites W1661568691 @default.
- W3049403629 cites W1838272947 @default.
- W3049403629 cites W1918892711 @default.
- W3049403629 cites W1956983065 @default.
- W3049403629 cites W1963871993 @default.
- W3049403629 cites W1968041782 @default.
- W3049403629 cites W1973109217 @default.
- W3049403629 cites W1978923298 @default.
- W3049403629 cites W1984513006 @default.
- W3049403629 cites W1994346896 @default.
- W3049403629 cites W2001263006 @default.
- W3049403629 cites W2004371621 @default.
- W3049403629 cites W2008197060 @default.
- W3049403629 cites W2016039923 @default.
- W3049403629 cites W2016069734 @default.
- W3049403629 cites W2021456245 @default.
- W3049403629 cites W2027220567 @default.
- W3049403629 cites W2034831738 @default.
- W3049403629 cites W2050450074 @default.
- W3049403629 cites W2052742260 @default.
- W3049403629 cites W2056598650 @default.
- W3049403629 cites W2057321407 @default.
- W3049403629 cites W2060878195 @default.
- W3049403629 cites W2066419835 @default.
- W3049403629 cites W2083500052 @default.
- W3049403629 cites W2084555860 @default.
- W3049403629 cites W2089730073 @default.
- W3049403629 cites W2093466456 @default.
- W3049403629 cites W2096882849 @default.
- W3049403629 cites W2117726740 @default.
- W3049403629 cites W2128969673 @default.
- W3049403629 cites W2133750804 @default.
- W3049403629 cites W2142283912 @default.
- W3049403629 cites W2148840336 @default.
- W3049403629 cites W2149203347 @default.
- W3049403629 cites W2169648500 @default.
- W3049403629 cites W2170446709 @default.
- W3049403629 cites W2302662562 @default.
- W3049403629 cites W2514003618 @default.
- W3049403629 cites W2566880751 @default.
- W3049403629 cites W2757022020 @default.
- W3049403629 cites W2765871628 @default.
- W3049403629 cites W2771944898 @default.
- W3049403629 cites W2790798430 @default.
- W3049403629 cites W2793683106 @default.
- W3049403629 cites W2796291568 @default.
- W3049403629 cites W2803006587 @default.
- W3049403629 cites W2808642220 @default.
- W3049403629 cites W2901070508 @default.
- W3049403629 cites W2908354619 @default.
- W3049403629 cites W2911993021 @default.
- W3049403629 cites W2918066696 @default.
- W3049403629 cites W2923575429 @default.
- W3049403629 cites W2994794797 @default.
- W3049403629 cites W3008420105 @default.
- W3049403629 doi "https://doi.org/10.3389/fnins.2020.00854" @default.
- W3049403629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7456872" @default.
- W3049403629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32922260" @default.
- W3049403629 hasPublicationYear "2020" @default.
- W3049403629 type Work @default.
- W3049403629 sameAs 3049403629 @default.
- W3049403629 citedByCount "1" @default.
- W3049403629 countsByYear W30494036292022 @default.
- W3049403629 crossrefType "journal-article" @default.
- W3049403629 hasAuthorship W3049403629A5033954219 @default.
- W3049403629 hasAuthorship W3049403629A5042840503 @default.
- W3049403629 hasAuthorship W3049403629A5043653028 @default.
- W3049403629 hasAuthorship W3049403629A5089818985 @default.
- W3049403629 hasBestOaLocation W30494036291 @default.
- W3049403629 hasConcept C102230213 @default.
- W3049403629 hasConcept C104317684 @default.
- W3049403629 hasConcept C121446783 @default.
- W3049403629 hasConcept C126322002 @default.
- W3049403629 hasConcept C134018914 @default.
- W3049403629 hasConcept C141035611 @default.
- W3049403629 hasConcept C178790620 @default.
- W3049403629 hasConcept C185592680 @default.
- W3049403629 hasConcept C535196362 @default.
- W3049403629 hasConcept C55493867 @default.
- W3049403629 hasConcept C71924100 @default.
- W3049403629 hasConcept C86803240 @default.
- W3049403629 hasConceptScore W3049403629C102230213 @default.
- W3049403629 hasConceptScore W3049403629C104317684 @default.
- W3049403629 hasConceptScore W3049403629C121446783 @default.
- W3049403629 hasConceptScore W3049403629C126322002 @default.
- W3049403629 hasConceptScore W3049403629C134018914 @default.
- W3049403629 hasConceptScore W3049403629C141035611 @default.
- W3049403629 hasConceptScore W3049403629C178790620 @default.
- W3049403629 hasConceptScore W3049403629C185592680 @default.