Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049445038> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3049445038 endingPage "12" @default.
- W3049445038 startingPage "1" @default.
- W3049445038 abstract "Cell therapies represent promising strategies to improve neurological functions after spinal cord injury (SCI). Olfactory mucosa (OM) might be an attractive source of multipotent cells for neuroregeneration because olfactory stem cells (OSCs) are resident. The regenerative capacity of OSCs has been demonstrated in animal models and some clinical case reports. Up to now, there are no standard methods for purification, characterization, and delivery of OSCs to the injury site. However, purification and characterization of the grafted cells are prerequisites for clinical use to ensure maximum safety for the patients. In this study, we isolated and purified OSCs from human OM using the neurosphere assay. Subsequently, the cells were characterized, and the behavior of purified OSCs in a plasma clot was investigated. Our study demonstrated that isolated cells from OM form neurospheres, which cells are positive for CD105 (98%) and CD90 (99%) and negative for Epcam (<1%) and MUC5AC (<1%). Purified OSCs were positive for Nestin, CD44 as well as GFAP and showed a lack of CD34 and CD45 expression. OSCs differentiated into neuron-like cells expressing ß-III tubulin. However, differentiation into adipocytes, chondrocytes or osteoblast could not be observed. In addition, OSCs stayed viable and were able to proliferate within the plasma clot. These results highlight OSC as a candidate for autologous transplantation in combination with the plasma clot as a cell carrier in SCI and neurodegenerative disease." @default.
- W3049445038 created "2020-08-21" @default.
- W3049445038 creator A5003080363 @default.
- W3049445038 creator A5003616006 @default.
- W3049445038 creator A5030184687 @default.
- W3049445038 creator A5030662638 @default.
- W3049445038 creator A5040037161 @default.
- W3049445038 creator A5041657331 @default.
- W3049445038 creator A5053524779 @default.
- W3049445038 creator A5079903456 @default.
- W3049445038 creator A5088099661 @default.
- W3049445038 date "2020-07-29" @default.
- W3049445038 modified "2023-09-23" @default.
- W3049445038 title "Olfactory Stem Cells for the Treatment of Spinal Cord Injury: Isolation, Purification and Behaviour in a Plasma Clot Matrix" @default.
- W3049445038 doi "https://doi.org/10.31487/j.rgm.2020.02.04" @default.
- W3049445038 hasPublicationYear "2020" @default.
- W3049445038 type Work @default.
- W3049445038 sameAs 3049445038 @default.
- W3049445038 citedByCount "0" @default.
- W3049445038 crossrefType "journal-article" @default.
- W3049445038 hasAuthorship W3049445038A5003080363 @default.
- W3049445038 hasAuthorship W3049445038A5003616006 @default.
- W3049445038 hasAuthorship W3049445038A5030184687 @default.
- W3049445038 hasAuthorship W3049445038A5030662638 @default.
- W3049445038 hasAuthorship W3049445038A5040037161 @default.
- W3049445038 hasAuthorship W3049445038A5041657331 @default.
- W3049445038 hasAuthorship W3049445038A5053524779 @default.
- W3049445038 hasAuthorship W3049445038A5079903456 @default.
- W3049445038 hasAuthorship W3049445038A5088099661 @default.
- W3049445038 hasBestOaLocation W30494450381 @default.
- W3049445038 hasConcept C10205521 @default.
- W3049445038 hasConcept C116716535 @default.
- W3049445038 hasConcept C123012128 @default.
- W3049445038 hasConcept C126322002 @default.
- W3049445038 hasConcept C1491633281 @default.
- W3049445038 hasConcept C154988683 @default.
- W3049445038 hasConcept C162746124 @default.
- W3049445038 hasConcept C169760540 @default.
- W3049445038 hasConcept C185592680 @default.
- W3049445038 hasConcept C202751555 @default.
- W3049445038 hasConcept C203014093 @default.
- W3049445038 hasConcept C20875687 @default.
- W3049445038 hasConcept C2778334475 @default.
- W3049445038 hasConcept C2780496858 @default.
- W3049445038 hasConcept C2780775167 @default.
- W3049445038 hasConcept C2780932548 @default.
- W3049445038 hasConcept C28328180 @default.
- W3049445038 hasConcept C502942594 @default.
- W3049445038 hasConcept C529278444 @default.
- W3049445038 hasConcept C55493867 @default.
- W3049445038 hasConcept C71924100 @default.
- W3049445038 hasConcept C86803240 @default.
- W3049445038 hasConcept C95444343 @default.
- W3049445038 hasConceptScore W3049445038C10205521 @default.
- W3049445038 hasConceptScore W3049445038C116716535 @default.
- W3049445038 hasConceptScore W3049445038C123012128 @default.
- W3049445038 hasConceptScore W3049445038C126322002 @default.
- W3049445038 hasConceptScore W3049445038C1491633281 @default.
- W3049445038 hasConceptScore W3049445038C154988683 @default.
- W3049445038 hasConceptScore W3049445038C162746124 @default.
- W3049445038 hasConceptScore W3049445038C169760540 @default.
- W3049445038 hasConceptScore W3049445038C185592680 @default.
- W3049445038 hasConceptScore W3049445038C202751555 @default.
- W3049445038 hasConceptScore W3049445038C203014093 @default.
- W3049445038 hasConceptScore W3049445038C20875687 @default.
- W3049445038 hasConceptScore W3049445038C2778334475 @default.
- W3049445038 hasConceptScore W3049445038C2780496858 @default.
- W3049445038 hasConceptScore W3049445038C2780775167 @default.
- W3049445038 hasConceptScore W3049445038C2780932548 @default.
- W3049445038 hasConceptScore W3049445038C28328180 @default.
- W3049445038 hasConceptScore W3049445038C502942594 @default.
- W3049445038 hasConceptScore W3049445038C529278444 @default.
- W3049445038 hasConceptScore W3049445038C55493867 @default.
- W3049445038 hasConceptScore W3049445038C71924100 @default.
- W3049445038 hasConceptScore W3049445038C86803240 @default.
- W3049445038 hasConceptScore W3049445038C95444343 @default.
- W3049445038 hasLocation W30494450381 @default.
- W3049445038 hasOpenAccess W3049445038 @default.
- W3049445038 hasPrimaryLocation W30494450381 @default.
- W3049445038 hasRelatedWork W1985190299 @default.
- W3049445038 hasRelatedWork W1996165380 @default.
- W3049445038 hasRelatedWork W2086943093 @default.
- W3049445038 hasRelatedWork W2160702731 @default.
- W3049445038 hasRelatedWork W2363170953 @default.
- W3049445038 hasRelatedWork W2375774916 @default.
- W3049445038 hasRelatedWork W2530671506 @default.
- W3049445038 hasRelatedWork W2732783500 @default.
- W3049445038 hasRelatedWork W2889854104 @default.
- W3049445038 hasRelatedWork W3049445038 @default.
- W3049445038 isParatext "false" @default.
- W3049445038 isRetracted "false" @default.
- W3049445038 magId "3049445038" @default.
- W3049445038 workType "article" @default.