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- W3049458056 abstract "Targeted therapy with tyrosine kinase inhibitors (TKI) has transformed the therapy of chronic myeloid leukaemia (CML), and is increasingly playing a role in the management of the myeloproliferative neoplasms (MPN), as a whole. In CML, the Philadelphia chromosome drives disease pathogenesis, and is the basis of both therapy (aimed at the BCR-ABL protein) and monitoring (the BCR-ABL chimeric mRNA). The efficacy of tyrosine kinase inhibitor therapy in CML is now accessed by reaching treatment milestones based on the BCR-ABL mRNA levels. In MPN, the landscape of genetic mutations associated with essential thrombocytosis (ET), polycythaemia vera (PV), and primary myelofibrosis (PMF) is ongoing. However, the recent discoveries of the JAK2 V617F and calreticulin mutations (for example) have a similar potential for disease targeting and monitoring as in CML." @default.
- W3049458056 created "2020-08-21" @default.
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- W3049458056 date "2020-07-01" @default.
- W3049458056 modified "2023-09-23" @default.
- W3049458056 title "Monitoring efforts in myeloproliferative neoplasms" @default.
- W3049458056 doi "https://doi.org/10.1093/med/9780198744214.003.0015" @default.
- W3049458056 hasPublicationYear "2020" @default.
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