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- W3049465055 endingPage "119133" @default.
- W3049465055 startingPage "119133" @default.
- W3049465055 abstract "MicroRNAs (i.e. miRNAs) are small non-coding RNAs that play essential modulation roles in embryonic development in vertebrates. Paternal and maternal miRNAs contribute to the development of post-fertilization embryo and zygotic genome activation. The pattern of expression and their roles in embryonic development of medaka are not clearly understood. The present study, therefore, examined a temporal expression of seven miRNAs, ola-let-7a, ola-miR-202-3p, ola-miR-126-3p, ola-miR-122, ola-miR-92a, ola-miR-125a-3p and ola-miR-430a in sperm, oocytes, and embryos during early developmental stages. Three unique expression patterns of miRNAs were observed. ola-let7a, ola-miR-202-3p and ola-miR-126-3p showed both paternal and maternal expression, and ola-miR-122, ola-miR-92a, ola-miR-125a-3p showed maternal expression only. The expression of six out of seven miRNAs significantly decreased after maternal-zygotic transition (MZT), whereas ola-miR-430a expression initiated only after MZT. The temporal dynamic expression of these miRNAs suggests their potential roles in early embryogenesis and genome-zygotic activation in medaka." @default.
- W3049465055 created "2020-08-21" @default.
- W3049465055 creator A5036929190 @default.
- W3049465055 creator A5053433380 @default.
- W3049465055 creator A5067315031 @default.
- W3049465055 date "2020-09-01" @default.
- W3049465055 modified "2023-10-18" @default.
- W3049465055 title "Distinct expression patterns of seven crucial microRNAs during early embryonic development in medaka (Oryzias latipes)" @default.
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- W3049465055 doi "https://doi.org/10.1016/j.gep.2020.119133" @default.
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