FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049508375> ?p ?o ?g. }

• W3049508375 endingPage "433" @default.
• W3049508375 startingPage "424" @default.
• W3049508375 abstract "Differentiated vulvar intraepithelial neoplasia (dVIN), the precursor lesion to human papillomavirus-independent vulvar squamous cell carcinoma (VSCC), can be difficult to distinguish from vulvar inflammatory dermatoses. Our goal was to determine if p53 could be a useful biomarker for dVIN, by characterizing p53 percentage, intensity and patterns of staining in dVIN and its histological mimics.We studied p53 immunohistochemical staining patterns in 16 dVIN cases and 46 vulvar non-neoplastic squamous lesions [12 lichen sclerosus (LS); seven lichen simplex chronicus; three lichen planus (LP); six psoriasis; 13 spongiotic dermatitis (SPO); and five candidiasis]. dVIN cases were adjacent to a p16-negative invasive VSCC in resection specimens. All dVIN cases showed null-type or moderate to strong uniform p53 staining in >70% of basal cells, with moderate to strong continuous parabasal staining extending to two-thirds of the epidermis. This was in contrast to weak or weak to moderate patchy p53 staining in the majority of other lesions. Moderate to strong and increased basal p53 staining (≥70%) was also observed in a subset of LS cases (5/12, 42%), LP cases (1/3, 33%), and SPO cases (36%, 4/11); however, in all categories, this was limited to the basal layer, and any staining in the parabasal layers was patchy.Strong and uniform p53 staining of basal cells, extending into the parabasal layers, and a complete absence of staining (null type) is useful in distinguishing dVIN from other mimics in the vulva. p53 staining of lesser intensity or quantity, particularly basal overexpression only, overlaps with that in vulvar inflammatory lesions." @default.
• W3049508375 created "2020-08-21" @default.
• W3049508375 creator A5013922346 @default.
• W3049508375 creator A5014743938 @default.
• W3049508375 creator A5015851482 @default.
• W3049508375 creator A5020385507 @default.
• W3049508375 creator A5028917424 @default.
• W3049508375 creator A5032474916 @default.
• W3049508375 creator A5055502131 @default.
• W3049508375 date "2020-10-27" @default.
• W3049508375 modified "2023-10-04" @default.
• W3049508375 title "Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva" @default.
• W3049508375 cites W1569310901 @default.
• W3049508375 cites W1977605539 @default.
• W3049508375 cites W1988340627 @default.
• W3049508375 cites W1995503371 @default.
• W3049508375 cites W1996033307 @default.
• W3049508375 cites W2000102903 @default.
• W3049508375 cites W2001541544 @default.
• W3049508375 cites W2002190835 @default.
• W3049508375 cites W2011477142 @default.
• W3049508375 cites W2013574475 @default.
• W3049508375 cites W2016602895 @default.
• W3049508375 cites W2017286235 @default.
• W3049508375 cites W2033737920 @default.
• W3049508375 cites W2036772997 @default.
• W3049508375 cites W2043613096 @default.
• W3049508375 cites W2054596765 @default.
• W3049508375 cites W2056573152 @default.
• W3049508375 cites W2056626408 @default.
• W3049508375 cites W2057300416 @default.
• W3049508375 cites W2065393455 @default.
• W3049508375 cites W2077850434 @default.
• W3049508375 cites W2085429487 @default.
• W3049508375 cites W2099714278 @default.
• W3049508375 cites W2108199617 @default.
• W3049508375 cites W2110433517 @default.
• W3049508375 cites W2128896886 @default.
• W3049508375 cites W2148234845 @default.
• W3049508375 cites W2159822855 @default.
• W3049508375 cites W2318972338 @default.
• W3049508375 cites W2321628205 @default.
• W3049508375 cites W2329057945 @default.
• W3049508375 cites W2342458645 @default.
• W3049508375 cites W2417320495 @default.
• W3049508375 cites W2556168824 @default.
• W3049508375 cites W2755791659 @default.
• W3049508375 cites W2768561234 @default.
• W3049508375 cites W2801778368 @default.
• W3049508375 cites W2907262316 @default.
• W3049508375 cites W2986365099 @default.
• W3049508375 cites W2995292698 @default.
• W3049508375 cites W3010961770 @default.
• W3049508375 cites W3014440652 @default.
• W3049508375 cites W3016511550 @default.
• W3049508375 cites W4251224857 @default.
• W3049508375 doi "https://doi.org/10.1111/his.14238" @default.
• W3049508375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32799363" @default.
• W3049508375 hasPublicationYear "2020" @default.
• W3049508375 type Work @default.
• W3049508375 sameAs 3049508375 @default.
• W3049508375 citedByCount "19" @default.
• W3049508375 countsByYear W30495083752020 @default.
• W3049508375 countsByYear W30495083752021 @default.
• W3049508375 countsByYear W30495083752022 @default.
• W3049508375 countsByYear W30495083752023 @default.
• W3049508375 crossrefType "journal-article" @default.
• W3049508375 hasAuthorship W3049508375A5013922346 @default.
• W3049508375 hasAuthorship W3049508375A5014743938 @default.
• W3049508375 hasAuthorship W3049508375A5015851482 @default.
• W3049508375 hasAuthorship W3049508375A5020385507 @default.
• W3049508375 hasAuthorship W3049508375A5028917424 @default.
• W3049508375 hasAuthorship W3049508375A5032474916 @default.
• W3049508375 hasAuthorship W3049508375A5055502131 @default.
• W3049508375 hasConcept C121608353 @default.
• W3049508375 hasConcept C134018914 @default.
• W3049508375 hasConcept C142724271 @default.
• W3049508375 hasConcept C16005928 @default.
• W3049508375 hasConcept C204232928 @default.
• W3049508375 hasConcept C2775924586 @default.
• W3049508375 hasConcept C2776316342 @default.
• W3049508375 hasConcept C2776552008 @default.
• W3049508375 hasConcept C2777343196 @default.
• W3049508375 hasConcept C2778024521 @default.
• W3049508375 hasConcept C2778220009 @default.
• W3049508375 hasConcept C2779306644 @default.
• W3049508375 hasConcept C2780564577 @default.
• W3049508375 hasConcept C2781076405 @default.
• W3049508375 hasConcept C2911206564 @default.
• W3049508375 hasConcept C54355233 @default.
• W3049508375 hasConcept C71924100 @default.
• W3049508375 hasConcept C74864618 @default.
• W3049508375 hasConcept C86803240 @default.
• W3049508375 hasConceptScore W3049508375C121608353 @default.
• W3049508375 hasConceptScore W3049508375C134018914 @default.
• W3049508375 hasConceptScore W3049508375C142724271 @default.
• W3049508375 hasConceptScore W3049508375C16005928 @default.
• W3049508375 hasConceptScore W3049508375C204232928 @default.

• next