FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049510393> ?p ?o ?g. }

• W3049510393 endingPage "1183" @default.
• W3049510393 startingPage "1183" @default.
• W3049510393 abstract "The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations. Here, we found that DesK—the transmembrane histidine kinase—also responds to pH and studied the mechanism of pH sensing. We propose that a helix linking the transmembrane region with the cytoplasmic catalytic domain is involved in pH sensing. This helix contains several glutamate, lysine, and arginine residues At neutral pH, the linker forms an alpha helix that is stabilized by hydrogen bonds in the i, i + 4 register and thus favors the kinase state. At low pH, protonation of glutamate residues breaks salt bridges, which results in helix destabilization and interruption of signaling. This mechanism inhibits unsaturated fatty acid synthesis and rigidifies the membrane when Bacillus grows in acidic conditions." @default.
• W3049510393 created "2020-08-21" @default.
• W3049510393 creator A5014135351 @default.
• W3049510393 creator A5027286823 @default.
• W3049510393 creator A5042030941 @default.
• W3049510393 creator A5054663913 @default.
• W3049510393 creator A5057239168 @default.
• W3049510393 creator A5058493776 @default.
• W3049510393 creator A5059234235 @default.
• W3049510393 creator A5068990419 @default.
• W3049510393 creator A5081907768 @default.
• W3049510393 date "2020-08-14" @default.
• W3049510393 modified "2023-10-06" @default.
• W3049510393 title "A Transmembrane Histidine Kinase Functions as a pH Sensor" @default.
• W3049510393 cites W1503601556 @default.
• W3049510393 cites W1967383045 @default.
• W3049510393 cites W2003141177 @default.
• W3049510393 cites W2021211500 @default.
• W3049510393 cites W2026626836 @default.
• W3049510393 cites W2034205936 @default.
• W3049510393 cites W2034405106 @default.
• W3049510393 cites W2050514815 @default.
• W3049510393 cites W2052498954 @default.
• W3049510393 cites W2062972150 @default.
• W3049510393 cites W2087082736 @default.
• W3049510393 cites W2123523275 @default.
• W3049510393 cites W2142331019 @default.
• W3049510393 cites W2145684516 @default.
• W3049510393 cites W2164695205 @default.
• W3049510393 cites W2194585050 @default.
• W3049510393 cites W2314517860 @default.
• W3049510393 cites W2520793553 @default.
• W3049510393 cites W2528504356 @default.
• W3049510393 cites W2553548740 @default.
• W3049510393 cites W2966578627 @default.
• W3049510393 cites W2991847931 @default.
• W3049510393 doi "https://doi.org/10.3390/biom10081183" @default.
• W3049510393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7465017" @default.
• W3049510393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32823946" @default.
• W3049510393 hasPublicationYear "2020" @default.
• W3049510393 type Work @default.
• W3049510393 sameAs 3049510393 @default.
• W3049510393 citedByCount "6" @default.
• W3049510393 countsByYear W30495103932021 @default.
• W3049510393 countsByYear W30495103932022 @default.
• W3049510393 countsByYear W30495103932023 @default.
• W3049510393 crossrefType "journal-article" @default.
• W3049510393 hasAuthorship W3049510393A5014135351 @default.
• W3049510393 hasAuthorship W3049510393A5027286823 @default.
• W3049510393 hasAuthorship W3049510393A5042030941 @default.
• W3049510393 hasAuthorship W3049510393A5054663913 @default.
• W3049510393 hasAuthorship W3049510393A5057239168 @default.
• W3049510393 hasAuthorship W3049510393A5058493776 @default.
• W3049510393 hasAuthorship W3049510393A5059234235 @default.
• W3049510393 hasAuthorship W3049510393A5068990419 @default.
• W3049510393 hasAuthorship W3049510393A5081907768 @default.
• W3049510393 hasBestOaLocation W30495103931 @default.
• W3049510393 hasConcept C104317684 @default.
• W3049510393 hasConcept C118892022 @default.
• W3049510393 hasConcept C12554922 @default.
• W3049510393 hasConcept C138223613 @default.
• W3049510393 hasConcept C143065580 @default.
• W3049510393 hasConcept C145148216 @default.
• W3049510393 hasConcept C170493617 @default.
• W3049510393 hasConcept C178790620 @default.
• W3049510393 hasConcept C184538305 @default.
• W3049510393 hasConcept C185592680 @default.
• W3049510393 hasConcept C18903297 @default.
• W3049510393 hasConcept C24530287 @default.
• W3049510393 hasConcept C2777272437 @default.
• W3049510393 hasConcept C2778460671 @default.
• W3049510393 hasConcept C2778530040 @default.
• W3049510393 hasConcept C2778905257 @default.
• W3049510393 hasConcept C2779965526 @default.
• W3049510393 hasConcept C30095370 @default.
• W3049510393 hasConcept C30765947 @default.
• W3049510393 hasConcept C47701112 @default.
• W3049510393 hasConcept C515207424 @default.
• W3049510393 hasConcept C523546767 @default.
• W3049510393 hasConcept C54355233 @default.
• W3049510393 hasConcept C55493867 @default.
• W3049510393 hasConcept C86803240 @default.
• W3049510393 hasConceptScore W3049510393C104317684 @default.
• W3049510393 hasConceptScore W3049510393C118892022 @default.
• W3049510393 hasConceptScore W3049510393C12554922 @default.
• W3049510393 hasConceptScore W3049510393C138223613 @default.
• W3049510393 hasConceptScore W3049510393C143065580 @default.
• W3049510393 hasConceptScore W3049510393C145148216 @default.
• W3049510393 hasConceptScore W3049510393C170493617 @default.
• W3049510393 hasConceptScore W3049510393C178790620 @default.
• W3049510393 hasConceptScore W3049510393C184538305 @default.
• W3049510393 hasConceptScore W3049510393C185592680 @default.
• W3049510393 hasConceptScore W3049510393C18903297 @default.
• W3049510393 hasConceptScore W3049510393C24530287 @default.
• W3049510393 hasConceptScore W3049510393C2777272437 @default.
• W3049510393 hasConceptScore W3049510393C2778460671 @default.
• W3049510393 hasConceptScore W3049510393C2778530040 @default.
• W3049510393 hasConceptScore W3049510393C2778905257 @default.

• next