Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049554448> ?p ?o ?g. }
- W3049554448 endingPage "102691" @default.
- W3049554448 startingPage "102691" @default.
- W3049554448 abstract "Heat acclimation (HA) induces metabolic plasticity to resist the effects of environmental heat with cross-tolerance to novel stressors such as oxygen supply perturbations, exercise, and alike. Our previous results indicated that hypoxia inducible transcription factor (HIF-1α) contributes to this adaptive process. In the present study, we link functional studies in isolated cardiomyocytes, with molecular and biochemical studies of cardiac mitochondria and demonstrate that HA remodels mitochondrial metabolism and performance. We observed the significant role that HIF-1α plays in the HA heart, as HA reduces oxidative stress during ischemia by shifting mitochondrial substrate preference towards pyruvate, with elevated level and activity of mitochondrial LDH (LDHb), acting a pivotal role. Increased antioxidative capacity to encounter hazards is implicated. These results deepen our understanding of heat acclimation-mediated cross tolerance (HACT), in which adaptive bioenergetic-mechanisms counteract the hazards of oxidative stress." @default.
- W3049554448 created "2020-08-21" @default.
- W3049554448 creator A5035023438 @default.
- W3049554448 creator A5037562795 @default.
- W3049554448 creator A5062073254 @default.
- W3049554448 creator A5071937184 @default.
- W3049554448 date "2020-10-01" @default.
- W3049554448 modified "2023-09-25" @default.
- W3049554448 title "Heat acclimation mediated cardioprotection is controlled by mitochondrial metabolic remodeling involving HIF-1α" @default.
- W3049554448 cites W1570410221 @default.
- W3049554448 cites W1819285150 @default.
- W3049554448 cites W1964569439 @default.
- W3049554448 cites W1966073486 @default.
- W3049554448 cites W1981170407 @default.
- W3049554448 cites W2004183689 @default.
- W3049554448 cites W2009457069 @default.
- W3049554448 cites W2029545663 @default.
- W3049554448 cites W2032782933 @default.
- W3049554448 cites W2035612080 @default.
- W3049554448 cites W2036753725 @default.
- W3049554448 cites W2054584109 @default.
- W3049554448 cites W2054987125 @default.
- W3049554448 cites W2077954885 @default.
- W3049554448 cites W2080127125 @default.
- W3049554448 cites W2089164902 @default.
- W3049554448 cites W2090010459 @default.
- W3049554448 cites W2098048070 @default.
- W3049554448 cites W2102526923 @default.
- W3049554448 cites W2109850854 @default.
- W3049554448 cites W2125035313 @default.
- W3049554448 cites W2135881241 @default.
- W3049554448 cites W2145774658 @default.
- W3049554448 cites W2152823402 @default.
- W3049554448 cites W2156345542 @default.
- W3049554448 cites W2166271462 @default.
- W3049554448 cites W2302805463 @default.
- W3049554448 cites W2415373443 @default.
- W3049554448 cites W2416531557 @default.
- W3049554448 cites W2417546929 @default.
- W3049554448 cites W2497714069 @default.
- W3049554448 cites W2531174801 @default.
- W3049554448 cites W2593968479 @default.
- W3049554448 cites W2608137234 @default.
- W3049554448 cites W2614673012 @default.
- W3049554448 cites W2740483385 @default.
- W3049554448 cites W2779746422 @default.
- W3049554448 cites W2795504602 @default.
- W3049554448 cites W2808517885 @default.
- W3049554448 cites W2899927301 @default.
- W3049554448 cites W2903884037 @default.
- W3049554448 cites W2921552993 @default.
- W3049554448 cites W2922129951 @default.
- W3049554448 cites W2947660950 @default.
- W3049554448 cites W3005469631 @default.
- W3049554448 cites W963616176 @default.
- W3049554448 cites W2796879831 @default.
- W3049554448 doi "https://doi.org/10.1016/j.jtherbio.2020.102691" @default.
- W3049554448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33077115" @default.
- W3049554448 hasPublicationYear "2020" @default.
- W3049554448 type Work @default.
- W3049554448 sameAs 3049554448 @default.
- W3049554448 citedByCount "7" @default.
- W3049554448 countsByYear W30495544482021 @default.
- W3049554448 countsByYear W30495544482023 @default.
- W3049554448 crossrefType "journal-article" @default.
- W3049554448 hasAuthorship W3049554448A5035023438 @default.
- W3049554448 hasAuthorship W3049554448A5037562795 @default.
- W3049554448 hasAuthorship W3049554448A5062073254 @default.
- W3049554448 hasAuthorship W3049554448A5071937184 @default.
- W3049554448 hasConcept C100206155 @default.
- W3049554448 hasConcept C119406331 @default.
- W3049554448 hasConcept C126322002 @default.
- W3049554448 hasConcept C178790620 @default.
- W3049554448 hasConcept C185592680 @default.
- W3049554448 hasConcept C18903297 @default.
- W3049554448 hasConcept C20251656 @default.
- W3049554448 hasConcept C2776151105 @default.
- W3049554448 hasConcept C2779676291 @default.
- W3049554448 hasConcept C28859421 @default.
- W3049554448 hasConcept C48349386 @default.
- W3049554448 hasConcept C540031477 @default.
- W3049554448 hasConcept C541997718 @default.
- W3049554448 hasConcept C55493867 @default.
- W3049554448 hasConcept C57600042 @default.
- W3049554448 hasConcept C62231903 @default.
- W3049554448 hasConcept C71924100 @default.
- W3049554448 hasConcept C7836513 @default.
- W3049554448 hasConcept C86803240 @default.
- W3049554448 hasConcept C95444343 @default.
- W3049554448 hasConceptScore W3049554448C100206155 @default.
- W3049554448 hasConceptScore W3049554448C119406331 @default.
- W3049554448 hasConceptScore W3049554448C126322002 @default.
- W3049554448 hasConceptScore W3049554448C178790620 @default.
- W3049554448 hasConceptScore W3049554448C185592680 @default.
- W3049554448 hasConceptScore W3049554448C18903297 @default.
- W3049554448 hasConceptScore W3049554448C20251656 @default.
- W3049554448 hasConceptScore W3049554448C2776151105 @default.
- W3049554448 hasConceptScore W3049554448C2779676291 @default.