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- W3049598974 abstract "Abstract Alzheimer's disease (AD), characterized by cognitive impairment and memory loss, accounts for most cases of dementia all over the world. Amyloid plaques and neurofibrillary tangles, hallmarks of AD, may stem from mitochondrial alterations though definite physiopathology, and hence disease-modifying drugs are lacking. Some 90% of patients suffering from AD develop at least one neuropsychiatric symptom; of these, agitation and aggression are the most resistant to treatment with atypical neuroleptics. Due to the high health risk posed by these drugs, complementary treatments with essential oils have been studied and have provided the best evidence for safety and effectiveness in the management of such symptoms. Agitation is tightly linked to underdetected and unrelieved pain; the latter is often present in the elderly, the population most affected by AD. An essential oil endowed with strong antinociceptive properties—e.g., bergamot—may represent a novel option for the handling of neuropsychiatric symptoms." @default.
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- W3049598974 date "2020-01-01" @default.
- W3049598974 modified "2023-10-06" @default.
- W3049598974 title "Exploitation of aromatherapy in dementia—impact on pain and neuropsychiatric symptoms" @default.
- W3049598974 doi "https://doi.org/10.1016/b978-0-12-815854-8.00045-8" @default.
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