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• W3049604411 abstract "Apoptotic cell clearance by phagocytes is a fundamental process during development, homeostasis and the resolution of inflammation. However, the demands placed on phagocytic cells such as macrophages by this process, and the limitations these interactions impose on subsequent cellular behaviours are not yet clear. Here, we seek to understand how apoptotic cells affect macrophage function in the context of a genetically tractable Drosophila model in which macrophages encounter excessive amounts of apoptotic cells. Loss of the glial-specific transcription factor Repo prevents glia from contributing to apoptotic cell clearance in the developing embryo. We show that this leads to the challenge of macrophages with large numbers of apoptotic cells in vivo. As a consequence, macrophages become highly vacuolated with cleared apoptotic cells, and their developmental dispersal and migration is perturbed. We also show that the requirement to deal with excess apoptosis caused by a loss of repo function leads to impaired inflammatory responses to injury. However, in contrast to migratory phenotypes, defects in wound responses cannot be rescued by preventing apoptosis from occurring within a repo mutant background. In investigating the underlying cause of these impaired inflammatory responses, we demonstrate that wound-induced calcium waves propagate into surrounding tissues, including neurons and glia of the ventral nerve cord, which exhibit striking calcium waves on wounding, revealing a previously unanticipated contribution of these cells during responses to injury. Taken together, these results demonstrate important insights into macrophage biology and how repo mutants can be used to study macrophage-apoptotic cell interactions in the fly embryo. Furthermore, this work shows how these multipurpose cells can be 'overtasked' to the detriment of their other functions, alongside providing new insights into which cells govern macrophage responses to injury in vivo." @default.
• W3049604411 created "2020-08-21" @default.
• W3049604411 creator A5015920256 @default.
• W3049604411 creator A5046503099 @default.
• W3049604411 creator A5090369459 @default.
• W3049604411 date "2020-08-14" @default.
• W3049604411 modified "2023-10-09" @default.
• W3049604411 title "Overexposure to apoptosis via disrupted glial specification perturbs Drosophila macrophage function and reveals roles of the CNS during injury" @default.
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• W3049604411 doi "https://doi.org/10.1038/s41419-020-02875-2" @default.
• W3049604411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7428013" @default.
• W3049604411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32796812" @default.
• W3049604411 hasPublicationYear "2020" @default.
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