FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049645934> ?p ?o ?g. }

• W3049645934 endingPage "111154" @default.
• W3049645934 startingPage "111154" @default.
• W3049645934 abstract "The study focused on the toxicological effect of Di-n-butyl phthalate (DBP) on the expression of Phosphorylated signal transducer and activator of transcription 1 (pSTAT1) -regulated Forkhead box protein M1 (FoxM1), which might provide a new understanding of gestational diabetes mellitus (GDM) development and a potential target for treatment. Streptozotocin (STZ) (40 mg/kg) was introduced in maternal rats by intraperitoneal injection on gestation day 0 (GD 0) in the STZ and STZ + DBP groups. DBP was introduced in maternal rats by oral feeding in the STZ + DBP group over the following 3 days (750 mg/kg/day). The changes in fasting blood glucose level in rats were detected on GD 1 and GD 5. The insulin levels in maternal rats and PIBCs were measured on GD 18. The Oral Glucose Tolerance Test (OGTT) test was performed on GD 18 to check the stability of the GDM model. The primary islet β cells (PIBCs) were established for in vitro experiments. We examined the FoxM1 and pSTAT1 expression in pancreas by immunohistochemistry. Real-time PCR and Western blot were used to detect the pSTAR1 and FoxM1 protein and mRNA gene expression levels in PIBCs. Cell Counting Kit-8 (CCK-8) and flow cytometric analysis was used to test the viability and apoptosis of cells. The results showed that the STZ + DBP group had higher glucose and lower insulin secretion levels than the other groups by both fasting test and OGTT. FoxM1 was significantly suppressed while pSTAT1 was highly expressed after DBP exposure. FoxM1 could be regulated by pSTAT1. DBP can influence the progression of GDM through its toxicological effect, which significantly increases the expression of pSTAT1 and suppresses FoxM1, causing a decline in β cell viability." @default.
• W3049645934 created "2020-08-21" @default.
• W3049645934 creator A5009774138 @default.
• W3049645934 creator A5010649560 @default.
• W3049645934 creator A5029810466 @default.
• W3049645934 creator A5035668668 @default.
• W3049645934 creator A5057297609 @default.
• W3049645934 creator A5059665113 @default.
• W3049645934 creator A5078175622 @default.
• W3049645934 creator A5080133364 @default.
• W3049645934 date "2020-12-01" @default.
• W3049645934 modified "2023-10-11" @default.
• W3049645934 title "Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling" @default.
• W3049645934 cites W1888149418 @default.
• W3049645934 cites W1966486733 @default.
• W3049645934 cites W1999278779 @default.
• W3049645934 cites W2089934320 @default.
• W3049645934 cites W2101147942 @default.
• W3049645934 cites W2104070694 @default.
• W3049645934 cites W2146561547 @default.
• W3049645934 cites W2292793709 @default.
• W3049645934 cites W2314718645 @default.
• W3049645934 cites W2346527683 @default.
• W3049645934 cites W2407055585 @default.
• W3049645934 cites W2490250055 @default.
• W3049645934 cites W2510963024 @default.
• W3049645934 cites W2592944953 @default.
• W3049645934 cites W2604284862 @default.
• W3049645934 cites W2769266397 @default.
• W3049645934 cites W2789635088 @default.
• W3049645934 cites W2791730980 @default.
• W3049645934 cites W2808075295 @default.
• W3049645934 cites W2897158557 @default.
• W3049645934 cites W2901911717 @default.
• W3049645934 cites W2903727029 @default.
• W3049645934 cites W2917514204 @default.
• W3049645934 cites W2921935358 @default.
• W3049645934 cites W2937814568 @default.
• W3049645934 cites W2941706526 @default.
• W3049645934 cites W2950735773 @default.
• W3049645934 cites W2950825841 @default.
• W3049645934 cites W2956138079 @default.
• W3049645934 cites W2961827336 @default.
• W3049645934 cites W2963341981 @default.
• W3049645934 cites W2978416675 @default.
• W3049645934 cites W2995606841 @default.
• W3049645934 cites W3005024462 @default.
• W3049645934 cites W3006415577 @default.
• W3049645934 cites W3007097837 @default.
• W3049645934 cites W3008320147 @default.
• W3049645934 cites W3008931470 @default.
• W3049645934 doi "https://doi.org/10.1016/j.ecoenv.2020.111154" @default.
• W3049645934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32810643" @default.
• W3049645934 hasPublicationYear "2020" @default.
• W3049645934 type Work @default.
• W3049645934 sameAs 3049645934 @default.
• W3049645934 citedByCount "14" @default.
• W3049645934 countsByYear W30496459342021 @default.
• W3049645934 countsByYear W30496459342022 @default.
• W3049645934 countsByYear W30496459342023 @default.
• W3049645934 crossrefType "journal-article" @default.
• W3049645934 hasAuthorship W3049645934A5009774138 @default.
• W3049645934 hasAuthorship W3049645934A5010649560 @default.
• W3049645934 hasAuthorship W3049645934A5029810466 @default.
• W3049645934 hasAuthorship W3049645934A5035668668 @default.
• W3049645934 hasAuthorship W3049645934A5057297609 @default.
• W3049645934 hasAuthorship W3049645934A5059665113 @default.
• W3049645934 hasAuthorship W3049645934A5078175622 @default.
• W3049645934 hasAuthorship W3049645934A5080133364 @default.
• W3049645934 hasBestOaLocation W30496459341 @default.
• W3049645934 hasConcept C126322002 @default.
• W3049645934 hasConcept C134018914 @default.
• W3049645934 hasConcept C178790620 @default.
• W3049645934 hasConcept C185592680 @default.
• W3049645934 hasConcept C2779234561 @default.
• W3049645934 hasConcept C2779280383 @default.
• W3049645934 hasConcept C2779306644 @default.
• W3049645934 hasConcept C2779434492 @default.
• W3049645934 hasConcept C2779643248 @default.
• W3049645934 hasConcept C2781005124 @default.
• W3049645934 hasConcept C46973012 @default.
• W3049645934 hasConcept C54355233 @default.
• W3049645934 hasConcept C555293320 @default.
• W3049645934 hasConcept C71924100 @default.
• W3049645934 hasConcept C86803240 @default.
• W3049645934 hasConceptScore W3049645934C126322002 @default.
• W3049645934 hasConceptScore W3049645934C134018914 @default.
• W3049645934 hasConceptScore W3049645934C178790620 @default.
• W3049645934 hasConceptScore W3049645934C185592680 @default.
• W3049645934 hasConceptScore W3049645934C2779234561 @default.
• W3049645934 hasConceptScore W3049645934C2779280383 @default.
• W3049645934 hasConceptScore W3049645934C2779306644 @default.
• W3049645934 hasConceptScore W3049645934C2779434492 @default.
• W3049645934 hasConceptScore W3049645934C2779643248 @default.
• W3049645934 hasConceptScore W3049645934C2781005124 @default.
• W3049645934 hasConceptScore W3049645934C46973012 @default.
• W3049645934 hasConceptScore W3049645934C54355233 @default.
• W3049645934 hasConceptScore W3049645934C555293320 @default.

• next