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- W3049677816 abstract "Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients." @default.
- W3049677816 created "2020-08-21" @default.
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- W3049677816 date "2020-10-01" @default.
- W3049677816 modified "2023-10-11" @default.
- W3049677816 title "Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease" @default.
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- W3049677816 doi "https://doi.org/10.1016/j.bandl.2020.104841" @default.
- W3049677816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8189666" @default.
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- W3049677816 hasPublicationYear "2020" @default.
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