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• W3049688049 endingPage "24" @default.
• W3049688049 startingPage "24" @default.
• W3049688049 abstract "Corneal opacity and neovascularization (NV) are often described as outcomes of severe herpes simplex virus type 1 (HSV-1) infection. The current study investigated the role of colony-stimulating factor 1 receptor (CSF1R)+ cells and soluble factors in the progression of HSV-1-induced corneal NV and opacity.MaFIA mice were infected with 500 plaque-forming units of HSV-1 in the cornea following scarification. From day 10 to day 13 post-infection (pi), mice were treated with 40 µg/day of AP20187 (macrophage ablation) or vehicle intraperitoneally. For osteopontin (OPN) neutralization experiments, C57BL/6 mice were infected as above and treated with 2 µg of goat anti-mouse OPN or isotypic control IgG subconjunctivally every 2 days from day 4 to day 12 pi. Mice were euthanized on day 14 pi, and tissue was processed for immunohistochemistry to quantify NV and opacity by confocal microscopy and absorbance or detection of pro- and anti-angiogenic and inflammatory factors and cells by suspension array analysis and flow cytometry, respectively.In the absence of CSF1R+ cells, HSV-1-induced blood and lymphatic vessel growth was muted. These results correlated with a loss in fibroblast growth factor type 2 (FGF-2) and an increase in OPN expression in the infected cornea. However, a reduction in OPN expression in mice did not alter corneal NV but significantly reduced opacity.Our data suggest that CSF1R+ cell depletion results in a significant reduction in HSV-1-induced corneal NV that correlates with the loss of FGF-2 expression. A reduction in OPN expression was aligned with a significant drop in opacity associated with reduced corneal collagen disruption." @default.
• W3049688049 created "2020-08-21" @default.
• W3049688049 creator A5002276285 @default.
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• W3049688049 date "2020-08-12" @default.
• W3049688049 modified "2023-10-12" @default.
• W3049688049 title "Loss of Osteopontin Expression Reduces HSV-1-Induced Corneal Opacity" @default.
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• W3049688049 doi "https://doi.org/10.1167/iovs.61.10.24" @default.
• W3049688049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7441335" @default.
• W3049688049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32785676" @default.
• W3049688049 hasPublicationYear "2020" @default.
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