FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049698269> ?p ?o ?g. }

• W3049698269 abstract "Abstract Background The incidence of cefepime-induced neurotoxicity (CIN) in hospitalized patients is highly variable. Although greater cefepime exposures incite neurotoxicity, data evaluating trough thresholds associated with CIN remains limited. The objectives of this study were to evaluate the incidence of CIN, assess the relationship between cefepime trough concentrations and CIN, investigate clinical factors associated with CIN, and describe electroencephalogram (EEG) abnormalities in CIN. Methods This was a retrospective study of adult patients who had received ≥ 5 days of cefepime with ≥ 1 trough concentration > 25 mg/L. Potential CIN cases were identified utilizing neurological symptoms, neurologist assessments, EEG findings and improvement of neurotoxicity after cefepime discontinuation. Results One-hundred and forty-two patients were included. The incidence of CIN was 13% (18/142). The mean cefepime trough concentration in CIN patients was significantly greater than the non-neurotoxicity group (74.2 mg/L ± 41.1 vs. 46.6 mg/L ± 23, p=0.015). Lower renal function (creatinine clearance < 30 ml/min), greater time to therapeutic drug monitoring (TDM) (≥72 hours), and each 1 mg/mL rise in cefepime trough were independently associated with increased risk of CIN. Moderate generalized slowing of the background rhythm was the most common EEG pattern associated with CIN. Conclusion Cefepime should be used cautiously in hospitalized patients due to the risk of neurotoxicity. Patients with greater renal function and those who had early cefepime TDM (≤ 72 hours) had lower risk of CIN." @default.
• W3049698269 created "2020-08-21" @default.
• W3049698269 creator A5027796696 @default.
• W3049698269 creator A5029619061 @default.
• W3049698269 creator A5030814492 @default.
• W3049698269 creator A5033321007 @default.
• W3049698269 creator A5037506185 @default.
• W3049698269 creator A5050301397 @default.
• W3049698269 creator A5051367948 @default.
• W3049698269 creator A5055231042 @default.
• W3049698269 creator A5064828307 @default.
• W3049698269 creator A5074442044 @default.
• W3049698269 creator A5076436914 @default.
• W3049698269 creator A5081264628 @default.
• W3049698269 date "2020-08-14" @default.
• W3049698269 modified "2023-10-16" @default.
• W3049698269 title "Use of Therapeutic Drug Monitoring to Characterize Cefepime-Induced Neurotoxicity" @default.
• W3049698269 cites W2012030884 @default.
• W3049698269 cites W2099627810 @default.
• W3049698269 cites W2133808321 @default.
• W3049698269 cites W2153655781 @default.
• W3049698269 cites W2158251453 @default.
• W3049698269 cites W2167943565 @default.
• W3049698269 cites W2169175461 @default.
• W3049698269 cites W2218326153 @default.
• W3049698269 cites W2283304113 @default.
• W3049698269 cites W2315878770 @default.
• W3049698269 cites W2566122931 @default.
• W3049698269 cites W2576933161 @default.
• W3049698269 cites W2770585743 @default.
• W3049698269 cites W2911444384 @default.
• W3049698269 cites W2953583576 @default.
• W3049698269 cites W2963325176 @default.
• W3049698269 cites W3037692841 @default.
• W3049698269 doi "https://doi.org/10.1101/2020.08.13.250456" @default.
• W3049698269 hasPublicationYear "2020" @default.
• W3049698269 type Work @default.
• W3049698269 sameAs 3049698269 @default.
• W3049698269 citedByCount "1" @default.
• W3049698269 countsByYear W30496982692022 @default.
• W3049698269 crossrefType "posted-content" @default.
• W3049698269 hasAuthorship W3049698269A5027796696 @default.
• W3049698269 hasAuthorship W3049698269A5029619061 @default.
• W3049698269 hasAuthorship W3049698269A5030814492 @default.
• W3049698269 hasAuthorship W3049698269A5033321007 @default.
• W3049698269 hasAuthorship W3049698269A5037506185 @default.
• W3049698269 hasAuthorship W3049698269A5050301397 @default.
• W3049698269 hasAuthorship W3049698269A5051367948 @default.
• W3049698269 hasAuthorship W3049698269A5055231042 @default.
• W3049698269 hasAuthorship W3049698269A5064828307 @default.
• W3049698269 hasAuthorship W3049698269A5074442044 @default.
• W3049698269 hasAuthorship W3049698269A5076436914 @default.
• W3049698269 hasAuthorship W3049698269A5081264628 @default.
• W3049698269 hasBestOaLocation W30496982691 @default.
• W3049698269 hasConcept C112705442 @default.
• W3049698269 hasConcept C120665830 @default.
• W3049698269 hasConcept C121332964 @default.
• W3049698269 hasConcept C126322002 @default.
• W3049698269 hasConcept C167135981 @default.
• W3049698269 hasConcept C185592680 @default.
• W3049698269 hasConcept C2777050379 @default.
• W3049698269 hasConcept C2778715236 @default.
• W3049698269 hasConcept C2779491297 @default.
• W3049698269 hasConcept C2779631663 @default.
• W3049698269 hasConcept C2780035454 @default.
• W3049698269 hasConcept C2780272996 @default.
• W3049698269 hasConcept C2910800852 @default.
• W3049698269 hasConcept C29730261 @default.
• W3049698269 hasConcept C42219234 @default.
• W3049698269 hasConcept C501593827 @default.
• W3049698269 hasConcept C55493867 @default.
• W3049698269 hasConcept C61511704 @default.
• W3049698269 hasConcept C71924100 @default.
• W3049698269 hasConcept C94665300 @default.
• W3049698269 hasConcept C98274493 @default.
• W3049698269 hasConceptScore W3049698269C112705442 @default.
• W3049698269 hasConceptScore W3049698269C120665830 @default.
• W3049698269 hasConceptScore W3049698269C121332964 @default.
• W3049698269 hasConceptScore W3049698269C126322002 @default.
• W3049698269 hasConceptScore W3049698269C167135981 @default.
• W3049698269 hasConceptScore W3049698269C185592680 @default.
• W3049698269 hasConceptScore W3049698269C2777050379 @default.
• W3049698269 hasConceptScore W3049698269C2778715236 @default.
• W3049698269 hasConceptScore W3049698269C2779491297 @default.
• W3049698269 hasConceptScore W3049698269C2779631663 @default.
• W3049698269 hasConceptScore W3049698269C2780035454 @default.
• W3049698269 hasConceptScore W3049698269C2780272996 @default.
• W3049698269 hasConceptScore W3049698269C2910800852 @default.
• W3049698269 hasConceptScore W3049698269C29730261 @default.
• W3049698269 hasConceptScore W3049698269C42219234 @default.
• W3049698269 hasConceptScore W3049698269C501593827 @default.
• W3049698269 hasConceptScore W3049698269C55493867 @default.
• W3049698269 hasConceptScore W3049698269C61511704 @default.
• W3049698269 hasConceptScore W3049698269C71924100 @default.
• W3049698269 hasConceptScore W3049698269C94665300 @default.
• W3049698269 hasConceptScore W3049698269C98274493 @default.
• W3049698269 hasLocation W30496982691 @default.
• W3049698269 hasOpenAccess W3049698269 @default.
• W3049698269 hasPrimaryLocation W30496982691 @default.
• W3049698269 hasRelatedWork W2099627810 @default.

• next