FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3049705428> ?p ?o ?g. }

• W3049705428 endingPage "S657" @default.
• W3049705428 startingPage "S648" @default.
• W3049705428 abstract "Abstract Background Clinical manifestations of respiratory syncytial virus (RSV) infection vary widely from mild, self-limiting illness to severe life-threatening disease. There are gaps in knowledge of biomarkers to objectively define severe disease and predict clinical outcomes. Methods A systematic search was performed, 1945–March 2019 in databases Ovid Medline, Embase, Global health, Scopus, and Web of Science. Risk of bias was assessed using the Cochrane tool. Results A total of 25 132 abstracts were screened and studies were assessed for quality, risk of bias, and extracted data; 111 studies met the inclusion criteria. RSV severity was correlated with antibody titers, reduced T and B cells, dysregulated innate immunity, neutrophil mobilization to the lungs and blood, decreased Th1 response, and Th2 weighted shift. Microbial exposures in respiratory tract may contribute to neutrophil mobilization to the lungs of the infants with severe RSV compared with mild RSV disease. Conclusions Although a wide range of biomarkers have been associated with RSV disease severity, robust validated biomarkers are lacking. This review illustrates the broad heterogeneity of study designs and high variability in the definition of severe RSV disease. Prospective studies are required to validate biomarkers. Additional research investigating epigenetics, metabolomics, and microbiome holds promise for novel biomarkers." @default.
• W3049705428 created "2020-08-21" @default.
• W3049705428 creator A5010594583 @default.
• W3049705428 creator A5024999096 @default.
• W3049705428 creator A5033344416 @default.
• W3049705428 creator A5033424442 @default.
• W3049705428 creator A5048949272 @default.
• W3049705428 creator A5055115480 @default.
• W3049705428 creator A5056054880 @default.
• W3049705428 creator A5065914659 @default.
• W3049705428 date "2020-08-14" @default.
• W3049705428 modified "2023-10-02" @default.
• W3049705428 title "Biomarkers for Disease Severity in Children Infected With Respiratory Syncytial Virus: A Systematic Literature Review" @default.
• W3049705428 cites W1483040325 @default.
• W3049705428 cites W1490006635 @default.
• W3049705428 cites W1610458787 @default.
• W3049705428 cites W1898603130 @default.
• W3049705428 cites W1964985824 @default.
• W3049705428 cites W1965360449 @default.
• W3049705428 cites W1980402776 @default.
• W3049705428 cites W1981680557 @default.
• W3049705428 cites W1985090881 @default.
• W3049705428 cites W1985207346 @default.
• W3049705428 cites W1986095162 @default.
• W3049705428 cites W1988008315 @default.
• W3049705428 cites W1992274963 @default.
• W3049705428 cites W2003139126 @default.
• W3049705428 cites W2004887426 @default.
• W3049705428 cites W2008935360 @default.
• W3049705428 cites W2011710883 @default.
• W3049705428 cites W2017802773 @default.
• W3049705428 cites W2030748537 @default.
• W3049705428 cites W2031889218 @default.
• W3049705428 cites W2034978765 @default.
• W3049705428 cites W2045782360 @default.
• W3049705428 cites W2052633053 @default.
• W3049705428 cites W2057869779 @default.
• W3049705428 cites W2059712674 @default.
• W3049705428 cites W2061039733 @default.
• W3049705428 cites W2064146393 @default.
• W3049705428 cites W2067818823 @default.
• W3049705428 cites W2070730673 @default.
• W3049705428 cites W2072241941 @default.
• W3049705428 cites W2072733585 @default.
• W3049705428 cites W2075332756 @default.
• W3049705428 cites W2077453690 @default.
• W3049705428 cites W2078706891 @default.
• W3049705428 cites W2081486092 @default.
• W3049705428 cites W2087846574 @default.
• W3049705428 cites W2091564177 @default.
• W3049705428 cites W2097382035 @default.
• W3049705428 cites W2100589529 @default.
• W3049705428 cites W2101114010 @default.
• W3049705428 cites W2106514725 @default.
• W3049705428 cites W2106552791 @default.
• W3049705428 cites W2110554565 @default.
• W3049705428 cites W2120544279 @default.
• W3049705428 cites W2126163156 @default.
• W3049705428 cites W2128364938 @default.
• W3049705428 cites W2131539372 @default.
• W3049705428 cites W2135879151 @default.
• W3049705428 cites W2140212933 @default.
• W3049705428 cites W2143485813 @default.
• W3049705428 cites W2151718822 @default.
• W3049705428 cites W2153357533 @default.
• W3049705428 cites W2159473587 @default.
• W3049705428 cites W2163733422 @default.
• W3049705428 cites W2257479343 @default.
• W3049705428 cites W2314943952 @default.
• W3049705428 cites W2336979047 @default.
• W3049705428 cites W2346069395 @default.
• W3049705428 cites W2401587445 @default.
• W3049705428 cites W2469823074 @default.
• W3049705428 cites W2518261009 @default.
• W3049705428 cites W2554114075 @default.
• W3049705428 cites W2581630074 @default.
• W3049705428 cites W2583763139 @default.
• W3049705428 cites W2586676015 @default.
• W3049705428 cites W2589772520 @default.
• W3049705428 cites W2727509207 @default.
• W3049705428 cites W2742191111 @default.
• W3049705428 cites W2752274657 @default.
• W3049705428 cites W2757615417 @default.
• W3049705428 cites W2763998628 @default.
• W3049705428 cites W2766824717 @default.
• W3049705428 cites W2783328678 @default.
• W3049705428 cites W2789414316 @default.
• W3049705428 cites W2888423166 @default.
• W3049705428 cites W2889794943 @default.
• W3049705428 cites W2896802097 @default.
• W3049705428 cites W2907016773 @default.
• W3049705428 cites W3022903699 @default.
• W3049705428 doi "https://doi.org/10.1093/infdis/jiaa208" @default.
• W3049705428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32794555" @default.
• W3049705428 hasPublicationYear "2020" @default.
• W3049705428 type Work @default.
• W3049705428 sameAs 3049705428 @default.
• W3049705428 citedByCount "8" @default.

• next