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• W3049762435 abstract "In Brief Nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, are used routinely in the treatment of primary headache disorders. Indomethacin is unique in its use in the diagnosis and treatment of hemicrania continua and paroxysmal hemicrania. The mechanism of this specific action is not fully understood, although an interaction with nitric oxide (NO) signaling pathways has been suggested. Trigeminovascular neurons were activated by dural electrical stimulation, systemic administration of an NO donor, or local microiontophoresis of L-glutamate. Using electrophysiological techniques, we subsequently recorded the activation of trigeminovascular neurons and their responses to intravenous indomethacin, naproxen, and ibuprofen. Administration of indomethacin (5 mg·kg−1), ibuprofen (30 mg·kg−1), or naproxen (30 mg·kg−1) inhibited dural-evoked firing within the trigeminocervical complex with different temporal profiles. Similarly, both indomethacin and naproxen inhibited L-glutamate-evoked cell firing suggesting a common action. By contrast, only indomethacin was able to inhibit NO-induced firing. The differences in profile of effect of indomethacin may be fundamental to its ability to treat paroxysmal hemicrania and hemicrania continua. The data implicate NO-related signaling as a potential therapeutic approach to these disorders. Indomethacin, naproxen, and ibuprofen inhibited nociceptive trigeminocervical neurons activated by stimulation of the dura mater, whereas only indomethacin inhibited responses activated by a nitric oxide donor." @default.
• W3049762435 created "2020-08-21" @default.
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• W3049762435 date "2020-08-06" @default.
• W3049762435 modified "2023-10-03" @default.
• W3049762435 title "Differential actions of indomethacin: clinical relevance in headache" @default.
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• W3049762435 doi "https://doi.org/10.1097/j.pain.0000000000002032" @default.
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