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• W3049852110 abstract "3D printed microfluidic devices are made of stiff and easy-to-fatigue materials and hence are difficult to have robust pneumatic valves. In this work, we describe a type of prefabricated polydimethylsiloxane (PDMS) valves, named the “Luer-lock” valve, which can be incorporated in 3D printed microfluidic devices utilizing the Luer-lock mechanism. Luer-lock design has been adopted for fluidic connections worldwide; it is facile, reliable, and inexpensive. To take advantage of the Luer-lock design, we added “valve ports” to our 3D printed microfluidic devices; prefabricated PDMS valve modules could be embedded into these valve ports, in a leak-free manner, by screwing tight the Luer-locks. In the experiment, we succeeded in fabricating pneumatic valves with a footprint diameter of 0.8 mm and verified the functionality of these valves with a shut-off pressure of 140 mbar and a maximal switching frequency of ∼1 Hz. As a demonstration, we show the serial encoding of core–shell hydrogel microfibers using the Luer-lock valves. Since the Luer-lock valves can be mass-produced and the CAD model of Luer-locks can be easily distributed, we believe that our approach has the potential to be easily adopted by researchers around the globe." @default.
• W3049852110 created "2020-08-24" @default.
• W3049852110 creator A5084373837 @default.
• W3049852110 date "2020-07-01" @default.
• W3049852110 modified "2023-10-03" @default.
• W3049852110 title "Luer-lock valve: A pre-fabricated pneumatic valve for 3D printed microfluidic automation" @default.
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• W3049852110 doi "https://doi.org/10.1063/5.0020531" @default.
• W3049852110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7440928" @default.
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