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• W3052098647 abstract "Abstract Breast cancers are divided into subtypes with different prognoses and treatment responses based on global differences in gene expression. Luminal breast cancer gene expression and proliferation are driven by estrogen receptor alpha, and targeting this transcription factor is the most effective therapy for this subtype. By contrast, it remains unclear which transcription factors drive the gene expression signature that defines basal-like triple-negative breast cancer, and there are no targeted therapies approved to treat this aggressive subtype. In this study, we utilized integrated genomic analysis of DNA methylation, chromatin accessibility, transcription factor binding, and gene expression in large collections of breast cancer cell lines and patient tumors to identify transcription factors responsible for the basal-like gene expression program. Glucocorticoid receptor (GR) and STAT3 bind to the same genomic regulatory regions, which were specifically open and unmethylated in basal-like breast cancer. These transcription factors cooperated to regulate expression of hundreds of genes in the basal-like gene expression signature, which were associated with poor prognosis. Combination treatment with small-molecule inhibitors of both transcription factors resulted in synergistic decreases in cell growth in cell lines and patient-derived organoid models. This study demonstrates that GR and STAT3 cooperate to regulate the basal-like breast cancer gene expression program and provides the basis for improved therapy for basal-like triple-negative breast cancer through rational combination of STAT3 and GR inhibitors. Significance: This study demonstrates that GR and STAT3 cooperate to activate the canonical gene expression signature of basal-like triple-negative breast cancer and that combination treatment with STAT3 and GR inhibitors could provide synergistic therapeutic efficacy." @default.
• W3052098647 created "2020-08-24" @default.
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• W3052098647 date "2020-10-15" @default.
• W3052098647 modified "2023-10-16" @default.
• W3052098647 title "STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer" @default.
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• W3052098647 cites W1972583198 @default.
• W3052098647 cites W2032580087 @default.
• W3052098647 cites W2033816932 @default.
• W3052098647 cites W2034428193 @default.
• W3052098647 cites W2044702943 @default.
• W3052098647 cites W2046406848 @default.
• W3052098647 cites W2056961869 @default.
• W3052098647 cites W2073759231 @default.
• W3052098647 cites W2074446011 @default.
• W3052098647 cites W2085934079 @default.
• W3052098647 cites W2096283457 @default.
• W3052098647 cites W2097255042 @default.
• W3052098647 cites W2102278945 @default.
• W3052098647 cites W2102619694 @default.
• W3052098647 cites W2103017472 @default.
• W3052098647 cites W2106425267 @default.
• W3052098647 cites W2108234281 @default.
• W3052098647 cites W2109882948 @default.
• W3052098647 cites W2111249775 @default.
• W3052098647 cites W2113231588 @default.
• W3052098647 cites W2113633750 @default.
• W3052098647 cites W2127192982 @default.
• W3052098647 cites W2128016314 @default.
• W3052098647 cites W2134539328 @default.
• W3052098647 cites W2138207763 @default.
• W3052098647 cites W2138258825 @default.
• W3052098647 cites W2142739240 @default.
• W3052098647 cites W2153086428 @default.
• W3052098647 cites W2153206149 @default.
• W3052098647 cites W2153454576 @default.
• W3052098647 cites W2156120082 @default.
• W3052098647 cites W2156661861 @default.
• W3052098647 cites W2157952888 @default.
• W3052098647 cites W2160779973 @default.
• W3052098647 cites W2162946128 @default.
• W3052098647 cites W2164111549 @default.
• W3052098647 cites W2166311434 @default.
• W3052098647 cites W2168086498 @default.
• W3052098647 cites W2170090299 @default.
• W3052098647 cites W2170602872 @default.
• W3052098647 cites W2171282302 @default.
• W3052098647 cites W2171808845 @default.
• W3052098647 cites W2179438025 @default.
• W3052098647 cites W2257497906 @default.
• W3052098647 cites W2259802687 @default.
• W3052098647 cites W2259938310 @default.
• W3052098647 cites W2265297933 @default.
• W3052098647 cites W2313296912 @default.
• W3052098647 cites W2341539131 @default.
• W3052098647 cites W2344726805 @default.
• W3052098647 cites W2430731787 @default.
• W3052098647 cites W2469802558 @default.
• W3052098647 cites W2472770902 @default.
• W3052098647 cites W2513942179 @default.
• W3052098647 cites W2560367415 @default.
• W3052098647 cites W2561249094 @default.
• W3052098647 cites W2562398320 @default.
• W3052098647 cites W2562561497 @default.
• W3052098647 cites W2591722461 @default.
• W3052098647 cites W2770178180 @default.
• W3052098647 cites W2794786066 @default.
• W3052098647 cites W2802308079 @default.
• W3052098647 cites W2807966236 @default.
• W3052098647 cites W2809413985 @default.
• W3052098647 cites W2898215009 @default.
• W3052098647 cites W2906052725 @default.
• W3052098647 cites W2917986762 @default.
• W3052098647 cites W2946899637 @default.
• W3052098647 cites W2992092023 @default.
• W3052098647 cites W3006494232 @default.
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• W3052098647 doi "https://doi.org/10.1158/0008-5472.can-20-1379" @default.
• W3052098647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32816914" @default.
• W3052098647 hasPublicationYear "2020" @default.
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