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- W3052556095 endingPage "157" @default.
- W3052556095 startingPage "146" @default.
- W3052556095 abstract "Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma. The primary goal of therapy is to reduce symptoms related to direct infiltration of the bone marrow and decrease monoclonal IgM-associated complications. Active agents in the management of WM can be broadly classified as rituximab-alkylator combination therapy, proteasome inhibitor-based therapy, and Bruton’s tyrosine kinase inhibitor-based therapy. <i>MYD88</i><sup>L265P</sup> and <i>CXCR4</i> genetic status are pivotal for tailoring treatment options. Ibrutinib is a suitable treatment option for both treatment-naïve and relapsing WM patients. Recent advances in the intracellular B cell and cytokine signaling pathways have contributed to the development of novel therapeutic strategies. Current clinical trials are promising and may further advance WM-directed therapy." @default.
- W3052556095 created "2020-08-24" @default.
- W3052556095 creator A5002248011 @default.
- W3052556095 creator A5007610928 @default.
- W3052556095 creator A5043508194 @default.
- W3052556095 date "2020-08-18" @default.
- W3052556095 modified "2023-10-12" @default.
- W3052556095 title "Current and Emerging Treatments for Waldenström Macroglobulinemia" @default.
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- W3052556095 doi "https://doi.org/10.1159/000509286" @default.
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