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- W3052972144 abstract "Significance Rod photoreceptor outer segments (OSs) are specialized ciliary architectures. Our imaging experiments reveal three properties of rods. First, intracellular calcium and key proteins have a concentration varying from the OS base to the tip. At the OS base, [Ca2+] i is approximately 80 nM and increases up to ∼200 nM at the OS tip; second, there are spontaneous calcium flares in functional OSs, and these flares are highly localized and are more pronounced at the OS tip; third, a bright flash of light at 488 nm induces a drop in [Ca2+] i at the OS base but often a flare at the OS tip. This structural and functional gradient of the phototransduction machinery is a fundamental aspect of transduction in vertebrate photoreceptors." @default.
- W3052972144 created "2020-08-24" @default.
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- W3052972144 date "2020-08-19" @default.
- W3052972144 modified "2023-10-15" @default.
- W3052972144 title "Calcium flares and compartmentalization in rod photoreceptors" @default.
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- W3052972144 doi "https://doi.org/10.1073/pnas.2004909117" @default.
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