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- W305372221 abstract "Phytochemical investigation of the stems of Eurycoma longifolia Jack led to the isolation of two new canthin-6-one alkaloids, 4,9-dimethoxycanthin-6-one (1) and 10-hydroxy-11-methoxycanthin-6-one (2), and a new tirucallane-type triterpenoid, 23,24,25-trihydroxytirucall-7-en-3,6-dione (3), along with 37 known compounds. Among these, an oxasqualenoid (4) was isolated as a natural product for the first time. The structures of the isolates were elucidated by spectroscopic and mass spectrometric means. All the isolates were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma cell line. Among them, 9,10-dimethoxycanthin-6-one (14, IC 50 = 5.0 μM), 10-hydroxy-9-methoxycanthin-6-one (15, IC 50 = 7.2 μM), dihydroniloticin (18, IC 50 = 8.2 μM), and 14-deacetyleurylene (34, IC 50 = 3.2 μM) displayed stronger activity than the positive control 5-FU (IC50 = 9.2 μM)." @default.
- W305372221 created "2016-06-24" @default.
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- W305372221 date "2010-01-01" @default.
- W305372221 modified "2023-09-26" @default.
- W305372221 title "Canthin-6-one Alkaloids and a Tirucallanoid from Eurycoma longifolia and Their Cytotoxic Activity against a Human HT-1080 Fibrosarcoma Cell Line" @default.
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- W305372221 doi "https://doi.org/10.1177/1934578x1000500105" @default.
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