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- W3055162682 abstract "Penicillium digitatum is the primary pathogen causing the green mold of citrus. The need for the development of higher effective and lower toxic natural antifungal agents is urgent, owing to the lack of antifungal agents that can successfully combat P. digitatum. Herein, the effects and mechanisms of 2-methoxy-1,4-naphthoquinone (MNQ) as a potential inhibitor of P. digitatumwere studied. First, MNQ showed a significant anti-P. digitatum effect with a minimum inhibitory concentration value of 5.0 μg/mL. Then, transcriptome, proteome, and metabolome profiling were performed on the MNQ-treated P. digitatum. A total of 910 genes, 297 proteins, and 174 metabolites changed significantly. The omics analysis indicated that it could be seen that MNQ mainly inhibits the growth of P. digitatum by affecting the synthesis of branched-chain amino acids and cell walls. These findings will be a great contribution to the further understanding of the possible molecular action of MNQ." @default.
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- W3055162682 date "2020-08-17" @default.
- W3055162682 modified "2023-10-12" @default.
- W3055162682 title "2-Methoxy-1,4-naphthoquinone Induces Metabolic Shifts in <i>Penicillium Digitatum</i> Revealed by High-Dimensional Biological Data" @default.
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- W3055162682 doi "https://doi.org/10.1021/acs.jafc.0c03396" @default.
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